Potential role of adherence traits of Escherichia coli in persistent diarrhea in an urban Brazilian slum - PubMed (original) (raw)
Potential role of adherence traits of Escherichia coli in persistent diarrhea in an urban Brazilian slum
C A Wanke et al. Pediatr Infect Dis J. 1991 Oct.
Abstract
We examined stools from 40 children with persistent diarrhea (duration, 14 days or more), from 50 children with acute diarrhea and from 38 control children to determine infectious etiologies for persistent diarrhea in Goncalves Dias, an urban favela (slum) in Fortaleza, Ceara, Brazil. Children with persistent diarrhea and children with acute diarrhea had similar rates of isolation of routine viral, bacterial and parasitic enteric pathogens. Routine pathogens were identified in at least 20% of cultures done more than 14 days into the diarrheal illness. We examined Escherichia coli isolated from these stools for adherence potential. Enteroaggregative E. coli were isolated significantly more often from children with persistent diarrhea than from control children or children with acute diarrhea (P less than 0.05). E. coli with hemagglutination patterns suggestive of adherence pili were also isolated more often from children with persistent diarrhea than from children with acute diarrhea (38% vs. 18%; P less than 0.05). Enterotoxigenic E. coli were isolated in combination with rotavirus more often from children with persistent diarrhea than from children with acute diarrhea. E. coli which were hydrophobic or exhibited hemagglutination were also seen more often in association with Giardia in children with persistent diarrhea. These findings suggest that the etiology of persistent diarrhea in children is complex and that the aggregative E. coli are associated with prolonged diarrheal illness. Although routine diarrheal pathogens may be present for more than 14 days, combinations of pathogens, including E. coli with adherence potential, may also contribute to prolonged diarrheal disease.
Similar articles
- Persistent diarrhea in northeast Brazil: etiologies and interactions with malnutrition.
Lima AA, Fang G, Schorling JB, de Albuquerque L, McAuliffe JF, Mota S, Leite R, Guerrant RL. Lima AA, et al. Acta Paediatr Suppl. 1992 Sep;381:39-44. doi: 10.1111/j.1651-2227.1992.tb12370.x. Acta Paediatr Suppl. 1992. PMID: 1421939 - Etiology of childhood diarrhea after rotavirus vaccine introduction: a prospective, population-based study in Nicaragua.
Becker-Dreps S, Bucardo F, Vilchez S, Zambrana LE, Liu L, Weber DJ, Peña R, Barclay L, Vinjé J, Hudgens MG, Nordgren J, Svensson L, Morgan DR, Espinoza F, Paniagua M. Becker-Dreps S, et al. Pediatr Infect Dis J. 2014 Nov;33(11):1156-63. doi: 10.1097/INF.0000000000000427. Pediatr Infect Dis J. 2014. PMID: 24879131 Free PMC article. - Association of torovirus with acute and persistent diarrhea in children.
Koopmans MP, Goosen ES, Lima AA, McAuliffe IT, Nataro JP, Barrett LJ, Glass RI, Guerrant RL. Koopmans MP, et al. Pediatr Infect Dis J. 1997 May;16(5):504-7. doi: 10.1097/00006454-199705000-00010. Pediatr Infect Dis J. 1997. PMID: 9154546 Clinical Trial. - Diarrhoeal disease: current concepts and future challenges. Enteroadherent Escherichia coli: a heterogeneous group of E. coli implicated as diarrhoeal pathogens.
Savarino SJ. Savarino SJ. Trans R Soc Trop Med Hyg. 1993 Dec;87 Suppl 3:49-53. doi: 10.1016/0035-9203(93)90539-3. Trans R Soc Trop Med Hyg. 1993. PMID: 8108852 Review. - [Acute diarrheal disease caused by enteropathogenic Escherichia coli in Colombia].
Gómez-Duarte OG. Gómez-Duarte OG. Rev Chilena Infectol. 2014 Oct;31(5):577-86. doi: 10.4067/S0716-10182014000500010. Rev Chilena Infectol. 2014. PMID: 25491457 Free PMC article. Review. Spanish.
Cited by
- High Burden of Co-Infection with Multiple Enteric Pathogens in Children Suffering with Diarrhoea from Rural and Peri-Urban Communities in South Africa.
Potgieter N, Heine L, Ngandu JPK, Ledwaba SE, Zitha T, Mudau LS, Becker P, Traore AN, Barnard TG. Potgieter N, et al. Pathogens. 2023 Feb 14;12(2):315. doi: 10.3390/pathogens12020315. Pathogens. 2023. PMID: 36839587 Free PMC article. - Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.
Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Margalef-Català M, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AW. Rajan A, et al. PLoS Pathog. 2020 Sep 28;16(9):e1008851. doi: 10.1371/journal.ppat.1008851. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32986782 Free PMC article. - Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids.
Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AW. Rajan A, et al. mBio. 2018 Feb 20;9(1):e02419-17. doi: 10.1128/mBio.02419-17. mBio. 2018. PMID: 29463660 Free PMC article. - Diarrheagenic Escherichia coli.
Gomes TA, Elias WP, Scaletsky IC, Guth BE, Rodrigues JF, Piazza RM, Ferreira LC, Martinez MB. Gomes TA, et al. Braz J Microbiol. 2016 Dec;47 Suppl 1(Suppl 1):3-30. doi: 10.1016/j.bjm.2016.10.015. Epub 2016 Nov 5. Braz J Microbiol. 2016. PMID: 27866935 Free PMC article. Review. - Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli.
Berry AA, Yang Y, Pakharukova N, Garnett JA, Lee WC, Cota E, Marchant J, Roy S, Tuittila M, Liu B, Inman KG, Ruiz-Perez F, Mandomando I, Nataro JP, Zavialov AV, Matthews S. Berry AA, et al. PLoS Pathog. 2014 Sep 18;10(9):e1004404. doi: 10.1371/journal.ppat.1004404. eCollection 2014 Sep. PLoS Pathog. 2014. PMID: 25232738 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical