Mechanism for regulating cell surface distribution of Na+,K(+)-ATPase in polarized epithelial cells - PubMed (original) (raw)

Comment

. 1991 Nov 8;254(5033):847-50.

doi: 10.1126/science.1658934.

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• PMID: 1658934
• DOI: 10.1126/science.1658934

Comment

Mechanism for regulating cell surface distribution of Na+,K(+)-ATPase in polarized epithelial cells

R W Hammerton et al. Science. 1991.

Abstract

Restriction of sodium, potassium adenosine triphosphatase (Na+,K(+)-ATPase) to either the apical or basal-lateral membrane domain of polarized epithelial cells is fundamental to vectorial ion and solute transport in many tissues and organs. A restricted membrane distribution of Na+,K(+)-ATPase in Madin-Darby canine kidney (MDCK) epithelial cells was found experimentally to be generated by preferential retention of active enzyme in the basal-lateral membrane domain and selective inactivation and loss from the apical membrane domain, rather than by vectorial targeting of newly synthesized protein from the Golgi complex to the basal-lateral membrane domain. These results show how different distributions of the same subunits of Na+,K(+)-ATPase may be generated in normal polarized epithelial and in disease states.

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Comment in

• Delivery of Na+,K(+)-ATPase in polarized epithelial cells.
  Zurzolo C, Rodriguez-Boulan E. Zurzolo C, et al. Science. 1993 Apr 23;260(5107):550-2; author reply 554-6. doi: 10.1126/science.8386394. Science. 1993. PMID: 8386394 No abstract available.
• Delivery of Na+,K(+)-ATPase in polarized epithelial cells.
  Gottardi CJ, Caplan MJ. Gottardi CJ, et al. Science. 1993 Apr 23;260(5107):552-4; author reply 554-6. doi: 10.1126/science.8386395. Science. 1993. PMID: 8386395 No abstract available.

Comment on

• Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.
  Hovis RR, Donovan JA, Musci MA, Motto DG, Goldman FD, Ross SE, Koretzky GA. Hovis RR, et al. Science. 1993 Apr 23;260(5107):544-6. doi: 10.1126/science.8475387. Science. 1993. PMID: 8475387

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