Mls--a retrovirus exploits the immune system - PubMed (original) (raw)
Review
Mls--a retrovirus exploits the immune system
H Acha-Orbea et al. Immunol Today. 1991 Oct.
Abstract
The identity of minor lymphocytes stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.
Comment in
- Immunosuppression by the MMTV superantigen?
Bentvelzen P. Bentvelzen P. Immunol Today. 1992 Feb;13(2):77. doi: 10.1016/0167-5699(92)90139-x. Immunol Today. 1992. PMID: 1315554 No abstract available.
Similar articles
- Mls superantigens: how retroviruses influence the expressed T cell receptor repertoire.
Huber BT. Huber BT. Semin Immunol. 1992 Oct;4(5):313-8. Semin Immunol. 1992. PMID: 1336681 Review. - Superantigens of mouse mammary tumor virus.
Acha-Orbea H, MacDonald HR. Acha-Orbea H, et al. Annu Rev Immunol. 1995;13:459-86. doi: 10.1146/annurev.iy.13.040195.002331. Annu Rev Immunol. 1995. PMID: 7612231 Review. - Infectious minor lymphocyte stimulating (Mls) antigens.
Acha-Orbea H, Waanders GA, Shakhov AN, Held W. Acha-Orbea H, et al. Semin Immunol. 1992 Oct;4(5):297-303. Semin Immunol. 1992. PMID: 1336680 Review. - Physiologic expression of two superantigens in the BDF1 mouse.
Gollob KJ, Palmer E. Gollob KJ, et al. J Immunol. 1991 Oct 15;147(8):2447-54. J Immunol. 1991. PMID: 1655891
Cited by
- Linking Human Betaretrovirus with Autoimmunity and Liver Disease in Patients with Primary Biliary Cholangitis.
Syed H, Penner T, Mason AL. Syed H, et al. Viruses. 2022 Aug 31;14(9):1941. doi: 10.3390/v14091941. Viruses. 2022. PMID: 36146750 Free PMC article. Review. - The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation.
Pérez AR, de Meis J, Rodriguez-Galan MC, Savino W. Pérez AR, et al. Front Immunol. 2020 Sep 2;11:1838. doi: 10.3389/fimmu.2020.01838. eCollection 2020. Front Immunol. 2020. PMID: 32983098 Free PMC article. Review. - Inherently variable responses to glucocorticoid stress among endogenous retroviruses isolated from 23 mouse strains.
Hsu K, Lee YK, Chew A, Chiu S, Lim D, Greenhalgh DG, Cho K. Hsu K, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2594-2600. doi: 10.1016/j.bbadis.2016.10.026. Epub 2016 Nov 3. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27816520 Free PMC article. - HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis.
Lin XW, Tang L, Yang J, Xu WH. Lin XW, et al. Biochim Biophys Acta. 2016 Nov;1863(11):2594-2603. doi: 10.1016/j.bbamcr.2016.07.007. Epub 2016 Jul 26. Biochim Biophys Acta. 2016. PMID: 27469241 - Combination antiretroviral studies for patients with primary biliary cirrhosis.
Lytvyak E, Montano-Loza AJ, Mason AL. Lytvyak E, et al. World J Gastroenterol. 2016 Jan 7;22(1):349-60. doi: 10.3748/wjg.v22.i1.349. World J Gastroenterol. 2016. PMID: 26755881 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials