C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women - PubMed (original) (raw)

C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women

Esther K Wei et al. Cancer Epidemiol Biomarkers Prev. 2006 Apr.

Abstract

Background: Determinants of insulin secretion and insulin-like growth factors (IGF) have been directly associated with risk for colorectal cancer. However, few studies have evaluated whether these factors are also associated with risk of colorectal adenoma, the main precursor lesion to colorectal cancer.

Methods: We identified 380 distal colorectal adenoma cases diagnosed between 1989 and 1998 and 380 controls among nondiabetic women from the cohort of 32,826 women, nested in the Nurses' Health Study, who provided blood samples in 1989 to 1990. Cases and controls were individually matched on year of birth, time period of and indication(s) for endoscopy, and date of blood draw.

Results: High concentrations of C-peptide, an indicator of insulin secretion, were statistically significantly associated with risk of distal colorectal adenoma [multivariable relative risk (MVRR) top versus bottom quartile, 1.63; 95% confidence interval (95% CI), 1.01-2.66; P = 0.01], even after including body mass index and physical activity in the statistical model. Fasting IGF binding protein-1 (IGFBP-1) concentrations did not show any clear association with risk for adenoma (MVRR top versus bottom quartile, 1.08; 95% CI, 0.56-2.07). These associations did not differ significantly by size/stage of adenoma. Glycosylated hemoglobin (HbA1c) was associated with a nonstatistically significant increased risk of colorectal adenoma (MVRR top versus bottom quartile, 1.47; 95% CI, 0.89-2.44).

Conclusions: High HbA1c and low IGFBP-1 were not clearly associated with increased risk of distal colorectal adenoma. However, our current results and previous associations between C-peptide and colorectal cancer suggest that hyperinsulinemia may play a role throughout the development of colorectal neoplasia.

PubMed Disclaimer

Cited by

Primary prevention of colorectal cancer.
Chan AT, Giovannucci EL. Chan AT, et al. Gastroenterology. 2010 Jun;138(6):2029-2043.e10. doi: 10.1053/j.gastro.2010.01.057. Gastroenterology. 2010. PMID: 20420944 Free PMC article. Review.
Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial.
Bobe G, Murphy G, Rogers CJ, Hance KW, Albert PS, Laiyemo AO, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. Bobe G, et al. Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1441-52. doi: 10.1158/1055-9965.EPI-09-1082. Epub 2010 May 25. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20501764 Free PMC article.
The two major epidemics of the twenty-first century: obesity and cancer.
Kaidar-Person O, Bar-Sela G, Person B. Kaidar-Person O, et al. Obes Surg. 2011 Nov;21(11):1792-7. doi: 10.1007/s11695-011-0490-2. Obes Surg. 2011. PMID: 21842287 Review.
A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer.
Mehta RS, Song M, Bezawada N, Wu K, Garcia-Albeniz X, Morikawa T, Fuchs CS, Ogino S, Giovannucci EL, Chan AT. Mehta RS, et al. J Natl Cancer Inst. 2014 Apr;106(4):dju016. doi: 10.1093/jnci/dju016. Epub 2014 Feb 24. J Natl Cancer Inst. 2014. PMID: 24565956 Free PMC article.
Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.
Hazra A, Fuchs CS, Chan AT, Giovannucci EL, Hunter DJ. Hazra A, et al. Cancer Causes Control. 2008 Nov;19(9):975-80. doi: 10.1007/s10552-008-9164-3. Epub 2008 May 14. Cancer Causes Control. 2008. PMID: 18478343 Free PMC article.

C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women - PubMed (original) (raw)