Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas - PubMed (original) (raw)
Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas
M S Meltzer et al. J Natl Cancer Inst. 1975 Jun.
Abstract
Tumor-specific antigens of cells of the diethylnitrosamine-induced hepatomas in strain-2 guinea pigs were extracted with 3 M KCl. Immunization of normal animals with the extracted tumor antigens in adjuvant protected them against a subsequent challenge with viable tumor cells. Extracted tumor-specific antigens were less effective immunogens than viable tumor cells for both of two antigenically distinct lines.
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