Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis - PubMed (original) (raw)

Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis

Errol C Friedberg. Mol Cell. 2006.

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Abstract

Deubiquitination of monoubiquitinated proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cysteine proteases in eukaryotic cells. Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation.

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