Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts - PubMed (original) (raw)
doi: 10.1038/ni1333. Epub 2006 Apr 23.
Chiho Homma, Yu Yang, Andres Hidalgo, Alexandre Garin, Frank Tacke, Veronique Angeli, Yansui Li, Peter Boros, Yaozhong Ding, Rolf Jessberger, Giorgio Trinchieri, Sergio A Lira, Gwendalyn J Randolph, Jonathan S Bromberg
Affiliations
- PMID: 16633346
- DOI: 10.1038/ni1333
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
Jordi C Ochando et al. Nat Immunol. 2006 Jun.
Abstract
The induction of alloantigen-specific unresponsiveness remains an elusive goal in organ transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen-presenting cells essential for tolerance to vascularized cardiac allografts. Tolerizing pDCs acquired alloantigen in the allograft and then moved through the blood to home to peripheral lymph nodes. In the lymph node, alloantigen-presenting pDCs induced the generation of CCR4+ CD4+ CD25+ Foxp3+ regulatory T cells (Treg cells). Depletion of pDCs or prevention of pDC lymph node homing inhibited peripheral Treg cell development and tolerance induction, whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolonged graft survival. Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance.
Comment in
- Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship?
Tang Q, Bluestone JA. Tang Q, et al. Nat Immunol. 2006 Jun;7(6):551-3. doi: 10.1038/ni0606-551. Nat Immunol. 2006. PMID: 16715063 No abstract available. - Literature watch: implications for transplantation.
Alessandrini A, Bromberg JS. Alessandrini A, et al. Am J Transplant. 2012 Nov;12(11):2867. doi: 10.1111/j.1600-6143.2012.04330.x. Am J Transplant. 2012. PMID: 23107267 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials