High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence - PubMed (original) (raw)
. 2006 Jun 1;193(11):1478-86.
doi: 10.1086/503780. Epub 2006 Apr 26.
Affiliations
- PMID: 16652274
- DOI: 10.1086/503780
High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
Catriona S Bradshaw et al. J Infect Dis. 2006.
Abstract
Background: We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence.
Methods: Women with symptomatic BV (a Nugent score [NS] of 7-10 or of 4-6 with >or=3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7-10.
Results: A total of 121 (87%) women with an NS of 7-10 and 18 (13%) with an NS of 4-6 and >or=3 Amsel criteria were enrolled; 130 (94%) returned >or=1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49%-66%]) had a recurrence of BV (NS 7-10), and 84 (69% [95% CI, 61%-77%]) had a recurrence of abnormal vaginal flora (NS 4-10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence.
Conclusion: Current recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV.
Comment in
- A persistent(ly) enigmatic ecological mystery: bacterial vaginosis.
Marrazzo JM. Marrazzo JM. J Infect Dis. 2006 Jun 1;193(11):1475-7. doi: 10.1086/503783. Epub 2006 Apr 26. J Infect Dis. 2006. PMID: 16652273 No abstract available. - Recurrence of symptomatic bacterial vaginosis 12 months after oral metronidazole therapy in HIV-positive and -negative women.
Myer L, Kuhn L, Denny L, Wright TC Jr. Myer L, et al. J Infect Dis. 2006 Dec 15;194(12):1797-9. doi: 10.1086/509625. J Infect Dis. 2006. PMID: 17109360 No abstract available. - Bacterial vaginosis: are we coming full circle?
Schwebke JR. Schwebke JR. J Infect Dis. 2009 Dec 1;200(11):1633-5. doi: 10.1086/648093. J Infect Dis. 2009. PMID: 19863440 No abstract available.
Similar articles
- The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy.
Bradshaw CS, Tabrizi SN, Fairley CK, Morton AN, Rudland E, Garland SM. Bradshaw CS, et al. J Infect Dis. 2006 Sep 15;194(6):828-36. doi: 10.1086/506621. Epub 2006 Aug 16. J Infect Dis. 2006. PMID: 16941351 - Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use.
Bradshaw CS, Vodstrcil LA, Hocking JS, Law M, Pirotta M, Garland SM, De Guingand D, Morton AN, Fairley CK. Bradshaw CS, et al. Clin Infect Dis. 2013 Mar;56(6):777-86. doi: 10.1093/cid/cis1030. Epub 2012 Dec 12. Clin Infect Dis. 2013. PMID: 23243173 Clinical Trial. - A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosis.
Schwebke JR, Desmond RA. Schwebke JR, et al. Clin Infect Dis. 2007 Jan 15;44(2):213-9. doi: 10.1086/509577. Epub 2006 Dec 13. Clin Infect Dis. 2007. PMID: 17173219 Clinical Trial. - Probiotics in the prevention of recurrences of bacterial vaginosis.
Parma M, Stella Vanni V, Bertini M, Candiani M. Parma M, et al. Altern Ther Health Med. 2014 Winter;20 Suppl 1:52-7. Altern Ther Health Med. 2014. PMID: 24473986 Review. - Utilisation of hydrogen peroxide in the treatment of recurrent bacterial vaginosis.
Cardone A, Zarcone R, Borrelli A, Di Cunzolo A, Russo A, Tartaglia E. Cardone A, et al. Minerva Ginecol. 2003 Dec;55(6):483-92. Minerva Ginecol. 2003. PMID: 14676737 Review. English, Italian.
Cited by
- Vaginal microbiota stability over 18 months in young student women in France.
Tamarelle J, Thiébaut ACM, de Barbeyrac B, Bébéar C, Bourret A, Fauconnier A, Ravel J, Delarocque-Astagneau E; i-Predict study group. Tamarelle J, et al. Eur J Clin Microbiol Infect Dis. 2024 Sep 20. doi: 10.1007/s10096-024-04943-3. Online ahead of print. Eur J Clin Microbiol Infect Dis. 2024. PMID: 39302529 - Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia Strongly Influence Each Other's Transcriptome in Triple-Species Biofilms.
Sousa LGV, Novak J, França A, Muzny CA, Cerca N. Sousa LGV, et al. Microb Ecol. 2024 Sep 19;87(1):117. doi: 10.1007/s00248-024-02433-9. Microb Ecol. 2024. PMID: 39294302 Free PMC article. - Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment.
Zhu M, Frank MW, Radka CD, Jeanfavre S, Xu J, Tse MW, Pacheco JA, Kim JS, Pierce K, Deik A, Hussain FA, Elsherbini J, Hussain S, Xulu N, Khan N, Pillay V, Mitchell CM, Dong KL, Ndung'u T, Clish CB, Rock CO, Blainey PC, Bloom SM, Kwon DS. Zhu M, et al. Cell. 2024 Sep 19;187(19):5413-5430.e29. doi: 10.1016/j.cell.2024.07.029. Epub 2024 Aug 19. Cell. 2024. PMID: 39163861 Free PMC article. - Gardnerella Species and Their Association With Bacterial Vaginosis.
Munch MM, Strenk SM, Srinivasan S, Fiedler TL, Proll S, Fredricks DN. Munch MM, et al. J Infect Dis. 2024 Jul 25;230(1):e171-e181. doi: 10.1093/infdis/jiae026. J Infect Dis. 2024. PMID: 39052736 Free PMC article. - The effectiveness of vaginal microbiota transplantation for vaginal dysbiosis and bacterial vaginosis: a scoping review.
Luo H, Zhou C, Zhou L, He Y, Xie RH. Luo H, et al. Arch Gynecol Obstet. 2024 Aug;310(2):643-653. doi: 10.1007/s00404-024-07611-1. Epub 2024 Jun 24. Arch Gynecol Obstet. 2024. PMID: 38914708 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous