Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord - PubMed (original) (raw)
Comparative Study
doi: 10.1002/glia.20354.
Affiliations
- PMID: 16673374
- DOI: 10.1002/glia.20354
Comparative Study
Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord
Masaaki Kitada et al. Glia. 2006 Jul.
Abstract
Oligodendrocytes and their precursors serve critical roles in the maintenance of neurological function. Although activity of the transcription factors (TFs) Olig1, Olig2, Sox10, and Nkx2.2 is required during early oligodendrocyte development, their later expression in adult central nervous system is rather poorly characterized. Here we have analyzed co-expression patterns of these transcriptional proteins in the mouse cervical spinal cord. Our findings indicate that TF co-expression patterns describe heterogeneity in adult oligodendroglial populations (1) in distinct sub-regions of grey and white matter and (2) with respect to level of maturation from proliferating precursors to myelinating oligodendrocytes. Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia.
Copyright 2005 Wiley-Liss, Inc.
Similar articles
- Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.
Finzsch M, Stolt CC, Lommes P, Wegner M. Finzsch M, et al. Development. 2008 Feb;135(4):637-46. doi: 10.1242/dev.010454. Epub 2008 Jan 9. Development. 2008. PMID: 18184726 - The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.
Zhou Q, Choi G, Anderson DJ. Zhou Q, et al. Neuron. 2001 Sep 13;31(5):791-807. doi: 10.1016/s0896-6273(01)00414-7. Neuron. 2001. PMID: 11567617 - Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms.
Liu Z, Hu X, Cai J, Liu B, Peng X, Wegner M, Qiu M. Liu Z, et al. Dev Biol. 2007 Feb 15;302(2):683-93. doi: 10.1016/j.ydbio.2006.10.007. Epub 2006 Oct 10. Dev Biol. 2007. PMID: 17098222 - Olig gene function in CNS development and disease.
Ligon KL, Fancy SP, Franklin RJ, Rowitch DH. Ligon KL, et al. Glia. 2006 Jul;54(1):1-10. doi: 10.1002/glia.20273. Glia. 2006. PMID: 16652341 Review. - Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives.
Woodruff RH, Tekki-Kessaris N, Stiles CD, Rowitch DH, Richardson WD. Woodruff RH, et al. Int J Dev Neurosci. 2001 Jul;19(4):379-85. doi: 10.1016/s0736-5748(00)00083-6. Int J Dev Neurosci. 2001. PMID: 11378298 Review.
Cited by
- CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo.
Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. Dietrich J, et al. J Biol. 2006;5(7):22. doi: 10.1186/jbiol50. J Biol. 2006. PMID: 17125495 Free PMC article. - Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve.
Jennings AR, Carroll WM. Jennings AR, et al. Brain Pathol. 2015 Sep;25(5):517-30. doi: 10.1111/bpa.12193. Epub 2014 Oct 29. Brain Pathol. 2015. PMID: 25175564 Free PMC article. - Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.
Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ. Zhao C, et al. J Neurosci. 2015 Aug 19;35(33):11482-99. doi: 10.1523/JNEUROSCI.3655-14.2015. J Neurosci. 2015. PMID: 26290228 Free PMC article. - Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis.
Zha Z, Gao YF, Ji J, Sun YQ, Li JL, Qi F, Zhang N, Jin LY, Xue B, Yang T, Fan YP, Zhao H, Wang L. Zha Z, et al. Oxid Med Cell Longev. 2021 Mar 16;2021:5521503. doi: 10.1155/2021/5521503. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33815654 Free PMC article. - Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH. Meijer DH, et al. Nat Rev Neurosci. 2012 Dec;13(12):819-31. doi: 10.1038/nrn3386. Nat Rev Neurosci. 2012. PMID: 23165259 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous