Developmental expression of two murine fibroblast growth factor receptors, flg and bek - PubMed (original) (raw)
Comparative Study
. 1991 Dec;113(4):1419-34.
doi: 10.1242/dev.113.4.1419.
Affiliations
- PMID: 1667382
- DOI: 10.1242/dev.113.4.1419
Comparative Study
Developmental expression of two murine fibroblast growth factor receptors, flg and bek
A Orr-Urtreger et al. Development. 1991 Dec.
Abstract
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.
Similar articles
- Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.
Peters KG, Werner S, Chen G, Williams LT. Peters KG, et al. Development. 1992 Jan;114(1):233-43. doi: 10.1242/dev.114.1.233. Development. 1992. PMID: 1315677 - Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo.
Yamaguchi TP, Conlon RA, Rossant J. Yamaguchi TP, et al. Dev Biol. 1992 Jul;152(1):75-88. doi: 10.1016/0012-1606(92)90157-c. Dev Biol. 1992. PMID: 1321062 - Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2).
Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P. Orr-Urtreger A, et al. Dev Biol. 1993 Aug;158(2):475-86. doi: 10.1006/dbio.1993.1205. Dev Biol. 1993. PMID: 8393815 - [Control of the positioning of the vertebrate limb axes during development].
Catala M. Catala M. Morphologie. 2000 Jun;84(265):17-23. Morphologie. 2000. PMID: 11048294 Review. French. - Mesoderm induction by fibroblast growth factor in early Xenopus development.
Slack JM, Darlington BG, Gillespie LL, Godsave SF, Isaacs HV, Paterno GD. Slack JM, et al. Philos Trans R Soc Lond B Biol Sci. 1990 Mar 12;327(1239):75-84. doi: 10.1098/rstb.1990.0044. Philos Trans R Soc Lond B Biol Sci. 1990. PMID: 1969663 Review.
Cited by
- A Transcriptomics Analysis of the Regulation of Lens Fiber Cell Differentiation in the Absence of FGFRs and PTEN.
Upreti A, Padula SL, Weaver JM, Wagner BD, Kneller AM, Petulla AL, Lachke SA, Robinson ML. Upreti A, et al. Cells. 2024 Jul 19;13(14):1222. doi: 10.3390/cells13141222. Cells. 2024. PMID: 39056803 Free PMC article. - Neuronal and mesodermal differentiation of P19 embryonal carcinoma cells is characterized by expression of specific marker genes and modulated by activin and fibroblast growth factors.
van der Kruijssen CMM, van Achterberg TAE, Feijen A, Hébert JM, de Waele P, van den Eijnden-van Raaij AJM. van der Kruijssen CMM, et al. Dev Growth Differ. 1995 Oct;37(5):559-574. doi: 10.1046/j.1440-169X.1995.t01-3-00011.x. Dev Growth Differ. 1995. PMID: 37280881 - Osteoarthritis: pathogenic signaling pathways and therapeutic targets.
Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y, He T, Chen S, Xiao G. Yao Q, et al. Signal Transduct Target Ther. 2023 Feb 3;8(1):56. doi: 10.1038/s41392-023-01330-w. Signal Transduct Target Ther. 2023. PMID: 36737426 Free PMC article. Review. - Stepwise pluripotency transitions in mouse stem cells.
Endoh M, Niwa H. Endoh M, et al. EMBO Rep. 2022 Sep 5;23(9):e55010. doi: 10.15252/embr.202255010. Epub 2022 Jul 29. EMBO Rep. 2022. PMID: 35903955 Free PMC article. Review. - Biological Significance and Targeting of the FGFR Axis in Cancer.
Chioni AM, Grose RP. Chioni AM, et al. Cancers (Basel). 2021 Nov 13;13(22):5681. doi: 10.3390/cancers13225681. Cancers (Basel). 2021. PMID: 34830836 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous