The embryonic vertebrate heart tube is a dynamic suction pump - PubMed (original) (raw)
. 2006 May 5;312(5774):751-3.
doi: 10.1126/science.1123775.
Affiliations
- PMID: 16675702
- DOI: 10.1126/science.1123775
Free article
The embryonic vertebrate heart tube is a dynamic suction pump
Arian S Forouhar et al. Science. 2006.
Free article
Abstract
The embryonic vertebrate heart begins pumping blood long before the development of discernable chambers and valves. At these early stages, the heart tube has been described as a peristaltic pump. Recent advances in confocal laser scanning microscopy and four-dimensional visualization have warranted another look at early cardiac structure and function. We examined the movement of cells in the embryonic zebrafish heart tube and the flow of blood through the heart and obtained results that contradict peristalsis as a pumping mechanism in the embryonic heart. We propose a more likely explanation of early cardiac dynamics in which the pumping action results from suction due to elastic wave propagation in the heart tube.
Similar articles
- Computational model for the transition from peristaltic to pulsatile flow in the embryonic heart tube.
Taber LA, Zhang J, Perucchio R. Taber LA, et al. J Biomech Eng. 2007 Jun;129(3):441-9. doi: 10.1115/1.2721076. J Biomech Eng. 2007. PMID: 17536912 - Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness.
Sharifi A, Gendernalik A, Garrity D, Bark D. Sharifi A, et al. Biomech Model Mechanobiol. 2021 Oct;20(5):2001-2012. doi: 10.1007/s10237-021-01489-7. Epub 2021 Jul 23. Biomech Model Mechanobiol. 2021. PMID: 34297252 - Flow within models of the vertebrate embryonic heart.
Santhanakrishnan A, Nguyen N, Cox JG, Miller LA. Santhanakrishnan A, et al. J Theor Biol. 2009 Aug 7;259(3):449-61. doi: 10.1016/j.jtbi.2009.04.020. Epub 2009 May 3. J Theor Biol. 2009. PMID: 19410580 - Cardiac chamber formation: development, genes, and evolution.
Moorman AF, Christoffels VM. Moorman AF, et al. Physiol Rev. 2003 Oct;83(4):1223-67. doi: 10.1152/physrev.00006.2003. Physiol Rev. 2003. PMID: 14506305 Review.
Cited by
- Molecular cloning and in silico analysis of the duck (Anas platyrhynchos) MEF2A gene cDNA and its expression profile in muscle tissues during fetal development.
Liu H, Wang J, Si J, Jia J, Li L, Han C, Huang K, He H, Xu F. Liu H, et al. Genet Mol Biol. 2012 Jan;35(1):182-90. doi: 10.1590/s1415-47572012005000023. Epub 2012 Feb 16. Genet Mol Biol. 2012. PMID: 22481893 Free PMC article. - Haemodynamic dependence of mechano-genetic evolution of the cardiovascular system in Japanese medaka.
Chakraborty S, Allmon E, Sepúlveda MS, Vlachos PP. Chakraborty S, et al. J R Soc Interface. 2021 Oct;18(183):20210752. doi: 10.1098/rsif.2021.0752. Epub 2021 Oct 27. J R Soc Interface. 2021. PMID: 34699728 Free PMC article. - Matters of the heart.
Bausek N, Zeidler MP. Bausek N, et al. JAKSTAT. 2012 Jul 1;1(3):208-10. doi: 10.4161/jkst.21361. JAKSTAT. 2012. PMID: 24058774 Free PMC article. - The living aortic valve: From molecules to function.
Chester AH, El-Hamamsy I, Butcher JT, Latif N, Bertazzo S, Yacoub MH. Chester AH, et al. Glob Cardiol Sci Pract. 2014 Jan 29;2014(1):52-77. doi: 10.5339/gcsp.2014.11. eCollection 2014. Glob Cardiol Sci Pract. 2014. PMID: 25054122 Free PMC article. Review. - On the Evolution of the Cardiac Pacemaker.
Burkhard S, van Eif V, Garric L, Christoffels VM, Bakkers J. Burkhard S, et al. J Cardiovasc Dev Dis. 2017 Apr 27;4(2):4. doi: 10.3390/jcdd4020004. J Cardiovasc Dev Dis. 2017. PMID: 29367536 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases