The limits of reductionism in medicine: could systems biology offer an alternative? - PubMed (original) (raw)
The limits of reductionism in medicine: could systems biology offer an alternative?
Andrew C Ahn et al. PLoS Med. 2006 May.
Abstract
In the first of a two part series, Ahn and colleagues discuss the reductionist approach pervading medicine and explain how a systems approach (as advocated by systems biology) may complement reductionism.
Conflict of interest statement
Competing Interests: The authors declare that they have no competing interests.
Figures
Figure 1. E. coli Chemotaxis
E. coli has been observed to migrate toward areas of higher aspartate concentrations through a series of “runs” and “tumbles” (see Box 1). Autophosph, autophosphorylation.
Similar articles
- Systems biology: integrating technology, biology, and computation.
Hood L. Hood L. Mech Ageing Dev. 2003 Jan;124(1):9-16. doi: 10.1016/s0047-6374(02)00164-1. Mech Ageing Dev. 2003. PMID: 12618001 - An integrated approach: systems biology seeks order in complexity.
Longtin R. Longtin R. J Natl Cancer Inst. 2005 Apr 6;97(7):476-8. doi: 10.1093/jnci/97.7.476. J Natl Cancer Inst. 2005. PMID: 15812068 No abstract available. - The conflict between complex systems and reductionism.
Heng HH. Heng HH. JAMA. 2008 Oct 1;300(13):1580-1. doi: 10.1001/jama.300.13.1580. JAMA. 2008. PMID: 18827215 No abstract available. - All systems go.
Powell K. Powell K. J Cell Biol. 2004 May 10;165(3):299-303. doi: 10.1083/jcb.200404013. Epub 2004 May 3. J Cell Biol. 2004. PMID: 15123734 Free PMC article. Review. - Conceptualizing compensatory responses: implications for treatment and research.
Fisher EM, Wineman NM. Fisher EM, et al. Biol Res Nurs. 2009 Apr;10(4):400-8. doi: 10.1177/1099800408324612. Epub 2008 Dec 28. Biol Res Nurs. 2009. PMID: 19114411 Review.
Cited by
- A complex, nonlinear dynamic systems perspective on Ayurveda and Ayurvedic research.
Rioux J. Rioux J. J Altern Complement Med. 2012 Jul;18(7):709-18. doi: 10.1089/acm.2011.0569. J Altern Complement Med. 2012. PMID: 22830972 Free PMC article. - Signaling between chloroplasts and the nucleus: can a systems biology approach bring clarity to a complex and highly regulated pathway?
Jung HS, Chory J. Jung HS, et al. Plant Physiol. 2010 Feb;152(2):453-9. doi: 10.1104/pp.109.149070. Epub 2009 Nov 20. Plant Physiol. 2010. PMID: 19933385 Free PMC article. No abstract available. - Unraveling patient heterogeneity in complex diseases through individualized co-expression networks: a perspective.
Latapiat V, Saez M, Pedroso I, Martin AJM. Latapiat V, et al. Front Genet. 2023 Aug 10;14:1209416. doi: 10.3389/fgene.2023.1209416. eCollection 2023. Front Genet. 2023. PMID: 37636264 Free PMC article. - Dupuytren's: a systems biology disease.
Rehman S, Goodacre R, Day PJ, Bayat A, Westerhoff HV. Rehman S, et al. Arthritis Res Ther. 2011;13(5):238. doi: 10.1186/ar3438. Epub 2011 Sep 12. Arthritis Res Ther. 2011. PMID: 21943049 Free PMC article. Review. - Why is it crucial to reintegrate pathology into cancer research?
Rodriguez-Canales J, Eberle FC, Jaffe ES, Emmert-Buck MR. Rodriguez-Canales J, et al. Bioessays. 2011 Jul;33(7):490-8. doi: 10.1002/bies.201100017. Epub 2011 May 17. Bioessays. 2011. PMID: 21590787 Free PMC article.
References
- Lindberg D. The beginnings of western science. Chicago: University of Chicago Press; 1992. 474 pp.
- Sweeney K, Kernick D. Clinical evaluation: Constructing a new model for postnormal medicine. J Eval Clin Pract. 2002;8:131–138. - PubMed
- Buchman TG. The community of self. Nature. 2002;420:246–251. - PubMed
- Zaloga G. Hypocalcemia in critically ill patients. Crit Care Med. 1992;20:251–262. - PubMed
- Zaloga G, Sager A, Black K, Prielipp R. Low dose calcium administration increases mortality during septic peritonitis in rates. Circ Shock. 1992;37:226–229. - PubMed
Publication types
MeSH terms
Grants and funding
- R01 HL072849/HL/NHLBI NIH HHS/United States
- R01-HL072849/HL/NHLBI NIH HHS/United States
- K24-AT000589/AT/NCCIH NIH HHS/United States
- T32-AT0051-03/AT/NCCIH NIH HHS/United States
- T32 AT000051/AT/NCCIH NIH HHS/United States
- K24 AT000589/AT/NCCIH NIH HHS/United States
LinkOut - more resources
Full Text Sources