Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice - PubMed (original) (raw)
Comparative Study
. 2006 May 18;50(4):617-29.
doi: 10.1016/j.neuron.2006.03.043.
Affiliations
- PMID: 16701211
- DOI: 10.1016/j.neuron.2006.03.043
Free article
Comparative Study
Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice
Isabelle Ferezou et al. Neuron. 2006.
Free article
Abstract
Voltage-sensitive dye imaging resolves the spatiotemporal dynamics of supragranular subthreshold cortical activity with millisecond temporal resolution and subcolumnar spatial resolution. We used a flexible fiber optic image bundle to visualize voltage-sensitive dye dynamics in the barrel cortex of freely moving mice while simultaneously filming whisker-related behavior to generate two movies matched frame-by-frame with a temporal resolution of up to 2 ms. Sensory responses evoked by passive whisker stimulation lasted longer and spread further across the barrel cortex in awake mice compared to anesthetized mice. Passively evoked sensory responses were large during behaviorally quiet periods and small during active whisking. However, as an exploring mouse approached an object while whisking, large-amplitude, propagating cortical sensory activity was evoked by active whisker-touch. These experiments demonstrate that fiber optics can be used to image cortical sensory activity with high resolution in freely moving animals. The results demonstrate differential processing of sensory input depending upon behavior.
Comment in
- Seeing what the mouse sees with its vibrissae: a matter of behavioral state.
Curtis JC, Kleinfeld D. Curtis JC, et al. Neuron. 2006 May 18;50(4):524-6. doi: 10.1016/j.neuron.2006.05.004. Neuron. 2006. PMID: 16701202 Free PMC article. Review.
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