Antimicrobial resistance of pneumococci in children with acute lower respiratory tract infection in Pakistan - PubMed (original) (raw)
Antimicrobial resistance of pneumococci in children with acute lower respiratory tract infection in Pakistan
T D Mastro et al. Lancet. 1991.
Abstract
87 strains of Streptococcus pneumoniae isolated during three winter seasons (1986-89) from the blood of children with acute lower respiratory tract infection (ALRI) in Pakistan were serotyped and tested for susceptibility to a range of antimicrobial agents. 97% of isolates were resistant to at least one antimicrobial drug. 62% had decreased susceptibility to co-trimoxazole (trimethoprim/sulphamethoxazole) (31% were fully resistant) and 39% were resistant to chloramphenicol. All isolates were susceptible to erythromycin, cefaclor, cephalothin, ceftriaxone, cefuroxime, rifampicin, vancomycin, and clindamycin. 29% of isolates were neither vaccine types nor vaccine-related types. Serotype distribution and antimicrobial susceptibility varied significantly during the three winter seasons. No single serotype was found in all three winters. The findings highlight the need for surveillance of antimicrobial resistance and serotype distribution of S pneumoniae in developing countries as a guide both to the choice of agent for treatment of pneumococcal infections, especially ALRI, and to the formulation of new pneumococcal conjugate vaccines for use in young children.
Comment in
- Penicillin-resistant pneumococci in Bangladeshi children.
Saha SK, Khan WA, Hoq MS, Salim AF, Akbar MS. Saha SK, et al. Lancet. 1991 Mar 23;337(8743):734-5. doi: 10.1016/0140-6736(91)90320-o. Lancet. 1991. PMID: 1672200 No abstract available.
Similar articles
- Antibiotic resistance of Streptococcus pneumoniae, isolated from nasopharynx of preschool children with acute respiratory tract infection in Lithuania.
Stacevičienė I, Petraitienė S, Vaičiūnienė D, Alasevičius T, Kirslienė J, Usonis V. Stacevičienė I, et al. BMC Infect Dis. 2016 May 20;16:216. doi: 10.1186/s12879-016-1544-9. BMC Infect Dis. 2016. PMID: 27206423 Free PMC article. - Use of nasopharyngeal isolates of Streptococcus pneumoniae and Haemophilus influenzae from children in Pakistan for surveillance for antimicrobial resistance.
Mastro TD, Nomani NK, Ishaq Z, Ghafoor A, Shaukat NF, Esko E, Leinonen M, Henrichsen J, Breiman RF, Schwartz B, et al. Mastro TD, et al. Pediatr Infect Dis J. 1993 Oct;12(10):824-30. doi: 10.1097/00006454-199310000-00006. Pediatr Infect Dis J. 1993. PMID: 8284119 - Serogroup distribution and antimicrobial resistance of nasopharyngeal isolates of Streptococcus pneumoniae among Beijing children with upper respiratory infections (2000-2005).
Yu S, Yao K, Shen X, Zhang W, Liu X, Yang Y. Yu S, et al. Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):649-55. doi: 10.1007/s10096-008-0481-y. Epub 2008 Mar 18. Eur J Clin Microbiol Infect Dis. 2008. PMID: 18347822 - Serotype distribution and antimicrobial susceptibility pattern in children≤5years with invasive pneumococcal disease in India - A systematic review.
Singh J, Sundaresan S, Manoharan A, Shet A. Singh J, et al. Vaccine. 2017 Aug 16;35(35 Pt B):4501-4509. doi: 10.1016/j.vaccine.2017.06.079. Epub 2017 Jul 12. Vaccine. 2017. PMID: 28711387 Review. - Current trends in bacterial respiratory pathogens.
Facklam RR, Breiman RF. Facklam RR, et al. Am J Med. 1991 Dec 30;91(6A):3S-11S. doi: 10.1016/0002-9343(91)90301-d. Am J Med. 1991. PMID: 1767804 Review.
Cited by
- Nasal carriage in Vietnamese children of Streptococcus pneumoniae resistant to multiple antimicrobial agents.
Parry CM, Diep TS, Wain J, Hoa NT, Gainsborough M, Nga D, Davies C, Phu NH, Hien TT, White NJ, Farrar JJ. Parry CM, et al. Antimicrob Agents Chemother. 2000 Mar;44(3):484-8. doi: 10.1128/AAC.44.3.484-488.2000. Antimicrob Agents Chemother. 2000. PMID: 10681307 Free PMC article. - Immunoglobulin G antibody responses to polyvalent pneumococcal vaccine in children in the highlands of Papua New Guinea.
Pomat WS, Lehmann D, Sanders RC, Lewis DJ, Wilson J, Rogers S, Dyke T, Alpers MP. Pomat WS, et al. Infect Immun. 1994 May;62(5):1848-53. doi: 10.1128/iai.62.5.1848-1853.1994. Infect Immun. 1994. PMID: 8168948 Free PMC article. - Comparison of standard versus double dose of amoxicillin in the treatment of non-severe pneumonia in children aged 2-59 months: a multi-centre, double blind, randomised controlled trial in Pakistan.
Hazir T, Qazi SA, Bin Nisar Y, Maqbool S, Asghar R, Iqbal I, Khalid S, Randhawa S, Aslam S, Riaz S, Abbasi S. Hazir T, et al. Arch Dis Child. 2007 Apr;92(4):291-7. doi: 10.1136/adc.2005.092494. Epub 2006 Mar 17. Arch Dis Child. 2007. PMID: 16547082 Free PMC article. Clinical Trial. - Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2-59 months in low resource settings: multicentre randomised controlled trial (SPEAR study).
Asghar R, Banajeh S, Egas J, Hibberd P, Iqbal I, Katep-Bwalya M, Kundi Z, Law P, MacLeod W, Maulen-Radovan I, Mino G, Saha S, Sempertegui F, Simon J, Santosham M, Singhi S, Thea DM, Qazi S; Severe Pneumonia Evaluation Antimicrobial Research Study Group. Asghar R, et al. BMJ. 2008 Jan 12;336(7635):80-4. doi: 10.1136/bmj.39421.435949.BE. Epub 2008 Jan 8. BMJ. 2008. PMID: 18182412 Free PMC article. Clinical Trial. - Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries.
Okeke IN, Lamikanra A, Edelman R. Okeke IN, et al. Emerg Infect Dis. 1999 Jan-Feb;5(1):18-27. doi: 10.3201/eid0501.990103. Emerg Infect Dis. 1999. PMID: 10081668 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical