p21-activated kinases in cancer - PubMed (original) (raw)
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doi: 10.1038/nrc1892.
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- PMID: 16723992
- DOI: 10.1038/nrc1892
Review
p21-activated kinases in cancer
Rakesh Kumar et al. Nat Rev Cancer. 2006 Jun.
Abstract
The pivotal role of kinases in signal transduction and cellular regulation has lent them considerable appeal as pharmacological targets across a broad spectrum of cancers. p21-activated kinases (Paks) are serine/threonine kinases that function as downstream nodes for various oncogenic signalling pathways. Paks are well-known regulators of cytoskeletal remodelling and cell motility, but have recently also been shown to promote cell proliferation, regulate apoptosis and accelerate mitotic abnormalities, which results in tumour formation and cell invasiveness. Alterations in Pak expression have been detected in human tumours, which makes them an attractive new therapeutic target.
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