Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation - PubMed (original) (raw)
Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation
B F Kjølby et al. Magn Reson Med. 2006 Jul.
Free article
Abstract
The concentration of MRI tracers cannot be measured directly by MRI and is commonly evaluated indirectly using their relaxation effect. This study develops a comprehensive theoretical model to describe the transverse relaxation in perfused tissue caused by intravascular tracers. The model takes into account a number of individual compartments. The signal dephasing is simulated in a semianalytical way by embedding Monte Carlo simulations in the framework of analytical theory. This approach yields a tool for fast, realistic simulation of the change in the transverse relaxation. The results indicate that the relaxivity of intravascular contrast agents depends significantly on the host tissue. This agrees with experimental data by Johnson et al. (Magn Reson Med 2000;44:909). In particular, the present results suggest a several-fold increase in the relaxivity of Gd-based contrast agents in brain tissue compared with bulk blood. The enhancement of relaxation in tissue is due to the contrast in magnetic susceptibility between blood vessels and parenchyma induced by the presence of paramagnetic tracer. Beyond the perfusion measurements, the results can be applied to quantitation of functional MRI and to vessel size imaging.
Copyright (c) 2006 Wiley-Liss, Inc.
Similar articles
- [Myocardial microcirculation in humans--new approaches using MRI].
Wacker CM, Bauer WR. Wacker CM, et al. Herz. 2003 Mar;28(2):74-81. doi: 10.1007/s00059-003-2451-6. Herz. 2003. PMID: 12669220 German. - Human whole blood 1 H2 O transverse relaxation with gadolinium-based contrast reagents: Magnetic susceptibility and transmembrane water exchange.
Wilson GJ, Springer CS Jr, Bastawrous S, Maki JH. Wilson GJ, et al. Magn Reson Med. 2017 May;77(5):2015-2027. doi: 10.1002/mrm.26284. Epub 2016 Jun 14. Magn Reson Med. 2017. PMID: 27297589 Free PMC article. - Correcting saturation effects of the arterial input function in dynamic susceptibility contrast-enhanced MRI: a Monte Carlo simulation.
Brunecker P, Villringer A, Schultze J, Nolte CH, Jungehülsing GJ, Endres M, Steinbrink J. Brunecker P, et al. Magn Reson Imaging. 2007 Nov;25(9):1300-11. doi: 10.1016/j.mri.2007.03.011. Epub 2007 Apr 26. Magn Reson Imaging. 2007. PMID: 17462846 - Multispectral quantitative magnetic resonance imaging of brain iron stores: a theoretical perspective.
Jara H, Sakai O, Mankal P, Irving RP, Norbash AM. Jara H, et al. Top Magn Reson Imaging. 2006 Feb;17(1):19-30. doi: 10.1097/01.rmr.0000245460.82782.69. Top Magn Reson Imaging. 2006. PMID: 17179894 Review. - Basic principles of magnetic resonance contrast agents.
Kirsch JE. Kirsch JE. Top Magn Reson Imaging. 1991 Mar;3(2):1-18. Top Magn Reson Imaging. 1991. PMID: 2025431 Review.
Cited by
- Contrast-free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges.
Vu C, Shen J, Gonzalez-Zacarias C, Xu B, Baas K, Choi S, Nederveen A, Wood JC. Vu C, et al. NMR Biomed. 2024 May;37(5):e5111. doi: 10.1002/nbm.5111. Epub 2024 Jan 31. NMR Biomed. 2024. PMID: 38297919 - DSC MRI in the human brain using deoxyhemoglobin and gadolinium-Simulations and validations at 3T.
Schulman JB, Sayin ES, Manalac A, Poublanc J, Sobczyk O, Duffin J, Fisher JA, Mikulis D, Uludağ K. Schulman JB, et al. Front Neuroimaging. 2023 Feb 20;2:1048652. doi: 10.3389/fnimg.2023.1048652. eCollection 2023. Front Neuroimaging. 2023. PMID: 37554650 Free PMC article. - Predicting the tissue outcome of acute ischemic stroke from acute 4D computed tomography perfusion imaging using temporal features and deep learning.
Winder AJ, Wilms M, Amador K, Flottmann F, Fiehler J, Forkert ND. Winder AJ, et al. Front Neurosci. 2022 Nov 4;16:1009654. doi: 10.3389/fnins.2022.1009654. eCollection 2022. Front Neurosci. 2022. PMID: 36408399 Free PMC article. - Towards differentiation of brain tumor from radiation necrosis using multi-parametric MRI: Preliminary results at 4.7 T using rodent models.
Devan SP, Jiang X, Kang H, Luo G, Xie J, Zu Z, Stokes AM, Gore JC, McKnight CD, Kirschner AN, Xu J. Devan SP, et al. Magn Reson Imaging. 2022 Dec;94:144-150. doi: 10.1016/j.mri.2022.10.002. Epub 2022 Oct 6. Magn Reson Imaging. 2022. PMID: 36209946 Free PMC article. - MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE): Simultaneous quantification of permeability and leakage-insensitive perfusion by dynamic T 1 / T 2 * mapping.
Hu Z, Christodoulou AG, Wang N, Xie Y, Shiroishi MS, Yang W, Zada G, Chow FE, Margol AS, Tamrazi B, Chang EL, Li D, Fan Z. Hu Z, et al. Magn Reson Med. 2023 Jan;89(1):161-176. doi: 10.1002/mrm.29431. Epub 2022 Sep 21. Magn Reson Med. 2023. PMID: 36128892 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical