Regulatory blueprint for a chordate embryo - PubMed (original) (raw)
. 2006 May 26;312(5777):1183-7.
doi: 10.1126/science.1123404.
Affiliations
- PMID: 16728634
- DOI: 10.1126/science.1123404
Regulatory blueprint for a chordate embryo
Kaoru S Imai et al. Science. 2006.
Abstract
Ciona is an emerging model system for elucidating gene networks in development. Comprehensive in situ hybridization assays have identified 76 regulatory genes with localized expression patterns in the early embryo, at the time when naïve blastomeres are determined to follow specific cell fates. Systematic gene disruption assays provided more than 3000 combinations of gene expression profiles in mutant backgrounds. Deduced gene circuit diagrams describing the formation of larval tissues were computationally visualized. These diagrams constitute a blueprint for the Ciona embryo and provide a foundation for understanding the evolutionary origins of the chordate body plan.
Comment in
- Developmental biology. How many ways to make a chordate?
Lemaire P. Lemaire P. Science. 2006 May 26;312(5777):1145-6. doi: 10.1126/science.1128784. Science. 2006. PMID: 16728621 No abstract available.
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