Mitochondrial NADPH, transhydrogenase and disease - PubMed (original) (raw)
. 2006 May-Jun;1757(5-6):721-6.
doi: 10.1016/j.bbabio.2006.03.010. Epub 2006 Apr 5.
Affiliations
- PMID: 16730324
- DOI: 10.1016/j.bbabio.2006.03.010
Free article
Mitochondrial NADPH, transhydrogenase and disease
Jan Rydström. Biochim Biophys Acta. 2006 May-Jun.
Free article
Abstract
Ever since its discovery in 1953 by N. O. Kaplan and coworkers, the physiological role of the proton-translocating transhydrogenase has generally been assumed to be that of generating mitochondrial NADPH. Mitochondrial NADPH can be used in a number of important reactions/processes, e.g., biosynthesis, maintenance of GSH, apoptosis, aging etc. This assumed role has found some support in bacteria but not in higher eukaryotes, a situation which changed dramatically with two recent but separate findings, both using transhydrogenase knockouts, in the nematode C. elegans and the mouse strain C57BL/6J. The latter, which is due to a spontaneous deletion mutation in the Nnt gene, was serendipitously found during investigations of the diabetic properties of these mice. The implications of these findings for the overall role of transhydrogenase in cell metabolism and disease are discussed.
Similar articles
- A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.
Ronchi JA, Figueira TR, Ravagnani FG, Oliveira HC, Vercesi AE, Castilho RF. Ronchi JA, et al. Free Radic Biol Med. 2013 Oct;63:446-56. doi: 10.1016/j.freeradbiomed.2013.05.049. Epub 2013 Jun 7. Free Radic Biol Med. 2013. PMID: 23747984 - Mitochondrial NAD(P)+ Transhydrogenase: From Molecular Features to Physiology and Disease.
Francisco A, Figueira TR, Castilho RF. Francisco A, et al. Antioxid Redox Signal. 2022 May;36(13-15):864-884. doi: 10.1089/ars.2021.0111. Epub 2021 Aug 5. Antioxid Redox Signal. 2022. PMID: 34155914 Review. - A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.
Arkblad EL, Tuck S, Pestov NB, Dmitriev RI, Kostina MB, Stenvall J, Tranberg M, Rydström J. Arkblad EL, et al. Free Radic Biol Med. 2005 Jun 1;38(11):1518-25. doi: 10.1016/j.freeradbiomed.2005.02.012. Free Radic Biol Med. 2005. PMID: 15890626 - A review of the binding-change mechanism for proton-translocating transhydrogenase.
Jackson JB. Jackson JB. Biochim Biophys Acta. 2012 Oct;1817(10):1839-46. doi: 10.1016/j.bbabio.2012.04.006. Epub 2012 Apr 17. Biochim Biophys Acta. 2012. PMID: 22538293 Review.
Cited by
- ALKBH8 contributes to neurological function through oxidative stress regulation.
Honda K, Hase H, Tanikawa S, Okawa K, Chen L, Yamaguchi T, Nakai M, Kitae K, Ago Y, Nakagawa S, Tsujikawa K. Honda K, et al. PNAS Nexus. 2024 Mar 28;3(3):pgae115. doi: 10.1093/pnasnexus/pgae115. eCollection 2024 Mar. PNAS Nexus. 2024. PMID: 38550277 Free PMC article. - The Structure of the Cardiac Mitochondria Respirasome Is Adapted for the β-Oxidation of Fatty Acids.
Panov AV. Panov AV. Int J Mol Sci. 2024 Feb 18;25(4):2410. doi: 10.3390/ijms25042410. Int J Mol Sci. 2024. PMID: 38397087 Free PMC article. Review. - Nystagmus in the B6(CG)Tyr(c-2J)/J Albino Mouse: A Functional and RNA-Seq Analysis.
Johnson LL, Abrahante JE, McLoon LK. Johnson LL, et al. Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):26. doi: 10.1167/iovs.65.1.26. Invest Ophthalmol Vis Sci. 2024. PMID: 38206276 Free PMC article. - Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry.
Kruglov AG, Romshin AM, Nikiforova AB, Plotnikova A, Vlasov II. Kruglov AG, et al. Int J Mol Sci. 2023 Nov 29;24(23):16955. doi: 10.3390/ijms242316955. Int J Mol Sci. 2023. PMID: 38069275 Free PMC article. Review. - Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis.
Nakamizo S, Sugiura Y, Ishida Y, Ueki Y, Yonekura S, Tanizaki H, Date H, Yoshizawa A, Murata T, Minatoya K, Katagiri M, Nomura S, Komuro I, Ogawa S, Nakajima S, Kambe N, Egawa G, Kabashima K. Nakamizo S, et al. J Clin Invest. 2023 Dec 1;133(23):e171088. doi: 10.1172/JCI171088. J Clin Invest. 2023. PMID: 38038136 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical