Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens - PubMed (original) (raw)

Comparative Study

doi: 10.1038/nn1713. Epub 2006 May 28.

Affiliations

• PMID: 16732275
• DOI: 10.1038/nn1713

Comparative Study

Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens

Miquel Martin et al. Nat Neurosci. 2006 Jul.

Abstract

The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression (LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long-lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.

PubMed Disclaimer

Similar articles

• Distinct contributions of dopamine receptors in the nucleus accumbens core or shell to established cocaine reinforcement under a second-order schedule.
  Di Ciano P. Di Ciano P. Eur Neuropsychopharmacol. 2008 Dec;18(12):888-96. doi: 10.1016/j.euroneuro.2008.07.007. Epub 2008 Aug 28. Eur Neuropsychopharmacol. 2008. PMID: 18760571
• Cooperative activation of D1-like and D2-like dopamine receptors in the nucleus accumbens shell is required for the reinstatement of cocaine-seeking behavior in the rat.
  Schmidt HD, Pierce RC. Schmidt HD, et al. Neuroscience. 2006 Oct 13;142(2):451-61. doi: 10.1016/j.neuroscience.2006.06.004. Epub 2006 Jul 14. Neuroscience. 2006. PMID: 16844308
• Accumbal neural responses during the initiation and maintenance of intravenous cocaine self-administration.
  Peoples LL, Lynch KG, Lesnock J, Gangadhar N. Peoples LL, et al. J Neurophysiol. 2004 Jan;91(1):314-23. doi: 10.1152/jn.00638.2003. Epub 2003 Oct 1. J Neurophysiol. 2004. PMID: 14523071
• Involvement of cholinergic neuronal systems in intravenous cocaine self-administration.
  Smith JE, Co C, Yin X, Sizemore GM, Liguori A, Johnson WE 3rd, Martin TJ. Smith JE, et al. Neurosci Biobehav Rev. 2004 Jan;27(8):841-50. doi: 10.1016/j.neubiorev.2003.11.002. Neurosci Biobehav Rev. 2004. PMID: 15019433 Review.
• Long-term gene expression in the nucleus accumbens following heroin administration is subregion-specific and depends on the nature of drug administration.
  Jacobs EH, Smit AB, de Vries TJ, Schoffelmeer AN. Jacobs EH, et al. Addict Biol. 2005 Mar;10(1):91-100. doi: 10.1080/13556210412331284748. Addict Biol. 2005. PMID: 15849023 Review.

Cited by

• Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction.
  Moussawi K, Kalivas PW. Moussawi K, et al. Eur J Pharmacol. 2010 Aug 10;639(1-3):115-22. doi: 10.1016/j.ejphar.2010.01.030. Epub 2010 Apr 2. Eur J Pharmacol. 2010. PMID: 20371233 Free PMC article. Review.
• Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction.
  Testen A, Sepulveda-Orengo MT, Gaines CH, Reissner KJ. Testen A, et al. Front Cell Neurosci. 2018 Aug 7;12:246. doi: 10.3389/fncel.2018.00246. eCollection 2018. Front Cell Neurosci. 2018. PMID: 30147645 Free PMC article.
• Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving.
  Lee BR, Ma YY, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y. Lee BR, et al. Nat Neurosci. 2013 Nov;16(11):1644-51. doi: 10.1038/nn.3533. Epub 2013 Sep 29. Nat Neurosci. 2013. PMID: 24077564 Free PMC article.
• Altered dendritic spine plasticity in cocaine-withdrawn rats.
  Shen HW, Toda S, Moussawi K, Bouknight A, Zahm DS, Kalivas PW. Shen HW, et al. J Neurosci. 2009 Mar 4;29(9):2876-84. doi: 10.1523/JNEUROSCI.5638-08.2009. J Neurosci. 2009. PMID: 19261883 Free PMC article.
• Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA.
  Chen BT, Bowers MS, Martin M, Hopf FW, Guillory AM, Carelli RM, Chou JK, Bonci A. Chen BT, et al. Neuron. 2008 Jul 31;59(2):288-97. doi: 10.1016/j.neuron.2008.05.024. Neuron. 2008. PMID: 18667156 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group