Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients - PubMed (original) (raw)

. 2006 Aug;49(8):1777-84.

doi: 10.1007/s00125-006-0294-4. Epub 2006 May 31.

A P S Kong, V W S Wong, W Y So, H L Y Chan, C S Ho, C W K Lam, J S Tam, C C Chow, C S Cockram, J C N Chan, P C Y Tong

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Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients

A Y S Cheng et al. Diabetologia. 2006 Aug.

Abstract

Aims/hypothesis: We examined the association between chronic hepatitis B virus (HBV) infection and clinical outcomes in a consecutive cohort of Chinese patients with type 2 diabetes.

Subjects, materials and methods: Between 1995 and 1999, 2,838 type 2 diabetes patients underwent comprehensive assessments and blood screening for hepatitis B surface antigen (HBsAg). The risk of occurrence of cardiovascular events and end-stage renal disease (defined as need for dialysis, doubling of serum creatinine or serum creatinine > or =500 micromol/l) was compared between HBsAg-positive and HBsAg-negative groups.

Results: At baseline, HBV-infected patients (n=286, 10.1%) were younger (51.0+/-11.5 vs 53.7+/-12.7 years, p=0.004), had earlier onset of diabetes (51.0+/-11.5 vs 53.7+/-12.7 years, p=0.001) and a higher frequency of retinopathy (28 vs 22%, p=0.03) than non-HBV-infected patients. After a median follow-up of 3.5 years (interquartile range: 1.7-5.9 years) and adjustment of age, glycaemic control and other potential confounding factors, HBV-infected patients were more likely to develop end-stage renal disease than non-HBV infected patients (8.7 vs 6.4%) with a hazard ratio of 4.5 (95% CI 1.1-18.6). The difference in the frequency of cardiovascular endpoints was not statistically significant.

Conclusions: In Chinese type 2 diabetes patients, chronic HBV infection was associated with increased risk of end-stage renal disease, and this was independent of other potential confounding factors. Early identification of HBV status and close surveillance of renal function are important in patients with type 2 diabetes who are living in areas where HBV is endemic or who are at risk of chronic HBV infection.

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References

    1. Clin Chem. 1972 Jun;18(6):499-502 - PubMed
    1. Diabetes Care. 2004 Jan;27(1):216-22 - PubMed
    1. Diabet Med. 2000 Oct;17(10):741-5 - PubMed
    1. Diabetologia. 2005 Jan;48(1):17-26 - PubMed
    1. Hepatology. 1999 Oct;30(4):1059-63 - PubMed

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