Rethinking the microprocessor - PubMed (original) (raw)
Review
. 2006 Jun 2;125(5):827-9.
doi: 10.1016/j.cell.2006.05.018.
Affiliations
- PMID: 16751089
- DOI: 10.1016/j.cell.2006.05.018
Free article
Review
Rethinking the microprocessor
Hervé Seitz et al. Cell. 2006.
Free article
Abstract
MicroRNAs (miRNAs) are tiny regulators of gene expression that are processed from longer primary transcripts. In this issue, Han et al. (2006) report some of the structural features of the primary transcript that ensure that the Drosha-DGCR8 enzyme complex liberates precisely the correct precursor sequence, enabling production of a fully functional miRNA.
Comment on
- Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN. Han J, et al. Cell. 2006 Jun 2;125(5):887-901. doi: 10.1016/j.cell.2006.03.043. Cell. 2006. PMID: 16751099
Similar articles
- Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN. Han J, et al. Cell. 2006 Jun 2;125(5):887-901. doi: 10.1016/j.cell.2006.03.043. Cell. 2006. PMID: 16751099 - The Microprocessor complex mediates the genesis of microRNAs.
Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R. Gregory RI, et al. Nature. 2004 Nov 11;432(7014):235-40. doi: 10.1038/nature03120. Epub 2004 Nov 7. Nature. 2004. PMID: 15531877 - The Drosha-DGCR8 complex in primary microRNA processing.
Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. Han J, et al. Genes Dev. 2004 Dec 15;18(24):3016-27. doi: 10.1101/gad.1262504. Epub 2004 Dec 1. Genes Dev. 2004. PMID: 15574589 Free PMC article. - Recognition and cleavage of primary microRNA transcripts.
Zeng Y, Cullen BR. Zeng Y, et al. Methods Mol Biol. 2006;342:49-56. doi: 10.1385/1-59745-123-1:49. Methods Mol Biol. 2006. PMID: 16957366 Review. - MicroRNA biogenesis: isolation and characterization of the microprocessor complex.
Gregory RI, Chendrimada TP, Shiekhattar R. Gregory RI, et al. Methods Mol Biol. 2006;342:33-47. doi: 10.1385/1-59745-123-1:33. Methods Mol Biol. 2006. PMID: 16957365 Review.
Cited by
- Mouse cytomegalovirus microRNAs dominate the cellular small RNA profile during lytic infection and show features of posttranscriptional regulation.
Dölken L, Perot J, Cognat V, Alioua A, John M, Soutschek J, Ruzsics Z, Koszinowski U, Voinnet O, Pfeffer S. Dölken L, et al. J Virol. 2007 Dec;81(24):13771-82. doi: 10.1128/JVI.01313-07. Epub 2007 Oct 17. J Virol. 2007. PMID: 17942535 Free PMC article. - Advances in microRNA biology.
Luhur A, Kumar JP. Luhur A, et al. Fly (Austin). 2008 May-Jun;2(3):123-4. doi: 10.4161/fly.6330. Epub 2008 May 23. Fly (Austin). 2008. PMID: 18820461 Free PMC article. No abstract available. - HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p.
Luo W, Xu Z, Wang H, Lu Z, Ding L, Wang R, Xie H, Zheng Q, Lin Y, Zhou Z, Li Y, Chen X, Li G, Xia L. Luo W, et al. Cell Biosci. 2023 Aug 18;13(1):153. doi: 10.1186/s13578-023-01094-4. Cell Biosci. 2023. PMID: 37596681 Free PMC article. - Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection.
Sullivan CS, Sung CK, Pack CD, Grundhoff A, Lukacher AE, Benjamin TL, Ganem D. Sullivan CS, et al. Virology. 2009 Apr 25;387(1):157-67. doi: 10.1016/j.virol.2009.02.017. Epub 2009 Mar 9. Virology. 2009. PMID: 19272626 Free PMC article. - Non-coding RNAs and neuroinflammation: implications for neurological disorders.
Chen Y, Mateski J, Gerace L, Wheeler J, Burl J, Prakash B, Svedin C, Amrick R, Adams BD. Chen Y, et al. Exp Biol Med (Maywood). 2024 Feb 28;249:10120. doi: 10.3389/ebm.2024.10120. eCollection 2024. Exp Biol Med (Maywood). 2024. PMID: 38463392 Free PMC article. Review.