Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclerosis - PubMed (original) (raw)
Relationship between serum uric acid concentration, metabolic syndrome and carotid atherosclerosis
Ryuichi Kawamoto et al. Intern Med. 2006.
Free article
Abstract
Objective: Carotid intima-media thickness (IMT) is a useful surrogate marker of cardiovascular disease. Associations between hyperuricemia, metabolic syndrome and carotid IMT have been reported, but few of the studies have been conducted in a Japanese population.
Methods: A total of 1,128 subjects (498 men aged, 68+/-14 years and 630 women aged 72+/-12 years) were divided into 4 groups according to serum uric acid (SUA) quartiles. We first investigated the association between SUA concentrations and metabolic syndrome; then, we assessed whether there is an independent association of SUA with carotid IMT in a population subdivided according to gender and metabolic syndrome status.
Results: In women, the prevalence of visceral obesity and metabolic syndrome were significantly increased with increased SUA quartiles, but not in men. After adjusting for age, smoking status, LDL-cholesterol, creatinine and history of diabetes mellitus, the odds ratios (95% CI) of sex-specific quartiles of SUA for metabolic syndrome were 1.0, 1.37 (0.79-2.37), 1.37 (0.79-2.38), and 1.80 (1.03-3.15) in men, and 1.0, 1.04 (0.56-1.94), 2.35 (1.30-4.22), and 2.20 (1.16-4.20) in women. After adjusting for various known risk factors, the prevalence of carotid atherosclerosis (IMT> or =1.0 mm) was higher in subjects in the second, third and fourth quartiles of SUA concentration with odds ratios (95% CI) of 2.41 (1.08-5.37), 3.33 (1.49-7.42), and 2.73 (1.17-6.35), respectively in men without metabolic syndrome but not in men with metabolic syndrome or in women with or without metabolic syndrome.
Conclusion: The prevalence of metabolic syndrome was significantly increased according to SUA values only in women. In men without metabolic syndrome, SUA was found to be an independent risk factor for incidence of carotid atherosclerosis.
Similar articles
- Uric acid level and its association with carotid intima-media thickness in patients with hypertension.
Tavil Y, Kaya MG, Oktar SO, Sen N, Okyay K, Yazici HU, Cengel A. Tavil Y, et al. Atherosclerosis. 2008 Mar;197(1):159-63. doi: 10.1016/j.atherosclerosis.2007.03.008. Epub 2007 Apr 9. Atherosclerosis. 2008. PMID: 17416371 - Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome.
Takayama S, Kawamoto R, Kusunoki T, Abe M, Onji M. Takayama S, et al. Cardiovasc Diabetol. 2012 Jan 10;11:2. doi: 10.1186/1475-2840-11-2. Cardiovasc Diabetol. 2012. PMID: 22234039 Free PMC article. - Metabolic syndrome amplifies the LDL-cholesterol associated increases in carotid atherosclerosis.
Kawamoto R, Tomita H, Oka Y, Kodama A, Kamitani A. Kawamoto R, et al. Intern Med. 2005 Dec;44(12):1232-8. doi: 10.2169/internalmedicine.44.1232. Intern Med. 2005. PMID: 16415542 - Association of obesity and visceral fat distribution with intima-media thickness of carotid arteries in middle-aged and older persons.
Kawamoto R, Ohtsuka N, Ninomiya D, Nakamura S. Kawamoto R, et al. Intern Med. 2008;47(3):143-9. doi: 10.2169/internalmedicine.47.0478. Epub 2008 Feb 1. Intern Med. 2008. PMID: 18239322 - Metabolic syndrome: an evolving threat in the genesis of coronary artery disease.
Jain P, Lahiri A. Jain P, et al. J Cardiometab Syndr. 2007 Summer;2(3):190-7. doi: 10.1111/j.1559-4564.2007.888105.x. J Cardiometab Syndr. 2007. PMID: 17786083 Review.
Cited by
- Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.
Liu L, He S, Jia L, Yao H, Zhou D, Guo X, Miao L. Liu L, et al. PLoS One. 2024 Apr 23;19(4):e0300582. doi: 10.1371/journal.pone.0300582. eCollection 2024. PLoS One. 2024. PMID: 38652726 Free PMC article. - High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study.
Wang X, Liu X, Qi Y, Zhang S, Shi K, Lin H, Grossfeld P, Wang W, Wu T, Qu X, Xiao J, Ye M. Wang X, et al. J Inflamm Res. 2022 Mar 12;15:1859-1872. doi: 10.2147/JIR.S353883. eCollection 2022. J Inflamm Res. 2022. PMID: 35310453 Free PMC article. - Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data.
Park JS, Kim Y, Kang J. Park JS, et al. J Hum Genet. 2022 Apr;67(4):231-237. doi: 10.1038/s10038-021-00991-1. Epub 2021 Nov 1. J Hum Genet. 2022. PMID: 34719683 - Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials.
Zong Q, Ma G, Wang T. Zong Q, et al. Afr Health Sci. 2021 Mar;21(1):82-95. doi: 10.4314/ahs.v21i1.13. Afr Health Sci. 2021. PMID: 34394285 Free PMC article. - Association of serum uric acid concentration with components of pediatric metabolic syndrome: A systematic review and meta-analysis.
Goli P, Riahi R, Daniali SS, Pourmirzaei M, Kelishadi R. Goli P, et al. J Res Med Sci. 2020 Apr 13;25:43. doi: 10.4103/jrms.JRMS_733_19. eCollection 2020. J Res Med Sci. 2020. PMID: 32582349 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical