Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats - PubMed (original) (raw)

. 2006 Nov 3;108(1):109-15.

doi: 10.1016/j.jep.2006.04.019. Epub 2006 May 2.

Affiliations

• PMID: 16759828
• DOI: 10.1016/j.jep.2006.04.019

Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats

Li-Qin Tang et al. J Ethnopharmacol. 2006.

Abstract

Berberine is the major active constituent of Rhizoma coptidis. The present study was carried out to investigate the effect of berberine on diabetes in rats and its possible mechanisms. Diabetes was induced by tail vein injection with alloxan in Wistar rats. The amount of alloxan administered was 55 mg/kg. Diabetic rats were fed with a high-cholesterol diet. The fasting blood glucose, total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c), nitric oxide (NO) levels in serum and malondialdehyde (MDA),superoxide dismutase (SOD),glutathione peroxidase (GSH-px) contents in heart tissue were assayed by spectrophotometry. Pancreas samples collected after 3 weeks of alloxan treatment were stained with hematoxylin-eosin (HE) and examined under a light microscope, and scored. Intragastric administration of berberine (100 and 200 mg/kg) significantly decreased fasting blood glucose levels, serum content of TC, TG, LDL-c, and effectively increased HDL-c, NO level in diabetic rats. Furthermore, berberine treatment significantly blocked the increase of MDA, increased SOD and GSH-px levels in diabetic rats. Histopathological scores showed that berberine had restored the damage of pancreas tissues in rats with diabetes mellitus. The results showed berberine significantly inhibited the progression of diabetes induced by alloxan, and the inhibitory effect of berberine on diabetes might be associated with its hypoglycemic effect, modulating lipids metabolic effects and its ability to scavenge free radical.

PubMed Disclaimer

Similar articles

• Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan-induced diabetic mice.
  Sharma N, Garg V. Sharma N, et al. Indian J Biochem Biophys. 2009 Feb;46(1):99-105. Indian J Biochem Biophys. 2009. PMID: 19374261
• Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.
  Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH. Sun JE, et al. J Ethnopharmacol. 2008 Jun 19;118(1):7-13. doi: 10.1016/j.jep.2008.02.030. Epub 2008 Mar 4. J Ethnopharmacol. 2008. PMID: 18434051
• Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan-induced diabetic rats.
  Gao D, Li Q, Li Y, Liu Z, Fan Y, Liu Z, Zhao H, Li J, Han Z. Gao D, et al. Phytother Res. 2009 Sep;23(9):1257-62. doi: 10.1002/ptr.2603. Phytother Res. 2009. PMID: 19274687
• Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms.
  Ni WJ, Ding HH, Tang LQ. Ni WJ, et al. Eur J Pharmacol. 2015 Aug 5;760:103-12. doi: 10.1016/j.ejphar.2015.04.017. Epub 2015 Apr 24. Eur J Pharmacol. 2015. PMID: 25912800 Review.
• [Progress of berberine for treatment of type 2 diabetes].
  Deng XW, Xie N. Deng XW, et al. Zhongguo Zhong Yao Za Zhi. 2014 Apr;39(8):1374-8. Zhongguo Zhong Yao Za Zhi. 2014. PMID: 25039167 Review. Chinese.

Cited by

• Interaction of herbal compounds with biological targets: a case study with berberine.
  Chen XW, Di YM, Zhang J, Zhou ZW, Li CG, Zhou SF. Chen XW, et al. ScientificWorldJournal. 2012;2012:708292. doi: 10.1100/2012/708292. Epub 2012 Nov 13. ScientificWorldJournal. 2012. PMID: 23213296 Free PMC article.
• Rhizoma Coptidis: A Potential Cardiovascular Protective Agent.
  Tan HL, Chan KG, Pusparajah P, Duangjai A, Saokaew S, Mehmood Khan T, Lee LH, Goh BH. Tan HL, et al. Front Pharmacol. 2016 Oct 7;7:362. doi: 10.3389/fphar.2016.00362. eCollection 2016. Front Pharmacol. 2016. PMID: 27774066 Free PMC article. Review.
• The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients.
  Shidfar F, Ebrahimi SS, Hosseini S, Heydari I, Shidfar S, Hajhassani G. Shidfar F, et al. Iran J Pharm Res. 2012 Spring;11(2):643-52. Iran J Pharm Res. 2012. PMID: 24250489 Free PMC article.
• Jiaotai Pill enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats.
  Dong H, Wang JH, Lu FE, Xu LJ, Gong YL, Zou X. Dong H, et al. Chin J Integr Med. 2013 Sep;19(9):668-74. doi: 10.1007/s11655-013-1560-1. Epub 2013 Aug 24. Chin J Integr Med. 2013. PMID: 23975131
• Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats.
  Wang FL, Tang LQ, Yang F, Zhu LN, Cai M, Wei W. Wang FL, et al. Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30. Mol Biol Rep. 2013. PMID: 23196710

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal