Antidepressants and pain - PubMed (original) (raw)
Review
Antidepressants and pain
Juan A Micó et al. Trends Pharmacol Sci. 2006 Jul.
Abstract
Tricyclic antidepressants, together with anticonvulsants, are considered to be first-line drugs for the treatment of neuropathic pain. Antidepressants are analgesic in patients with chronic pain and no concomitant depression, indicating that the analgesic and antidepressant effects occur independently. The analgesia induced by these drugs seems to be centrally mediated but consistent evidence also indicates a peripheral site of action. Several pharmacological mechanisms account for their antinociceptive effect but the inhibition of monoamine transporters (and, consequently, the facilitation of descending inhibition pain systems) is implicated on the basis of mechanistic and knockout-mouse studies. However, pain is a common symptom of depression, and depression is frequent in chronic pain patients, supporting the hypothesis that pain and depression share some common biochemical mechanisms. We suggest that antidepressants have a genuine analgesic effect and that research into their mechanisms of action will help to facilitate the development of new drugs.
Similar articles
- Therapeutic applications and mechanisms of action of monoamine oxidase inhibitor and heterocyclic antidepressant drugs.
Goodman WK, Charney DS. Goodman WK, et al. J Clin Psychiatry. 1985 Oct;46(10 Pt 2):6-24. J Clin Psychiatry. 1985. PMID: 3900056 Review. - Efficacy of duloxetine in painful symptoms: an analgesic or antidepressant effect?
Perahia DG, Pritchett YL, Desaiah D, Raskin J. Perahia DG, et al. Int Clin Psychopharmacol. 2006 Nov;21(6):311-7. doi: 10.1097/01.yic.0000224782.83287.3c. Int Clin Psychopharmacol. 2006. PMID: 17012978 Review. - Analgesic effects of antidepressants.
Fishbain DA. Fishbain DA. J Clin Psychiatry. 2003 Jan;64(1):96; author reply 96-7. J Clin Psychiatry. 2003. PMID: 12590632 No abstract available. - Antidepressants and antiepileptic drugs for chronic non-cancer pain.
Maizels M, McCarberg B. Maizels M, et al. Am Fam Physician. 2005 Feb 1;71(3):483-90. Am Fam Physician. 2005. PMID: 15712623 Review.
Cited by
- Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits.
Copits BA, Pullen MY, Gereau RW 4th. Copits BA, et al. Pain. 2016 Nov;157(11):2424-2433. doi: 10.1097/j.pain.0000000000000620. Pain. 2016. PMID: 27340912 Free PMC article. Review. No abstract available. - Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.
Rosenberg MB, Carroll FI, Negus SS. Rosenberg MB, et al. J Pain. 2013 Mar;14(3):246-59. doi: 10.1016/j.jpain.2012.11.006. Epub 2013 Jan 16. J Pain. 2013. PMID: 23332494 Free PMC article. - Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs.
Mehr-un-Nisa, Munawar MA, Lee YS, Rankin D, Munir J, Lai J, Khan MA, Hruby VJ. Mehr-un-Nisa, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1251-9. doi: 10.1016/j.bmc.2015.01.047. Epub 2015 Feb 3. Bioorg Med Chem. 2015. PMID: 25703306 Free PMC article. - [Tapentadol: with two mechanisms of action in one molecule effective against nociceptive and neuropathic pain. Preclinical overview].
Tzschentke TM, Christoph T, Schröder W, Englberger W, De Vry J, Jahnel U, Kögel BY. Tzschentke TM, et al. Schmerz. 2011 Feb;25(1):19-25. doi: 10.1007/s00482-010-1004-1. Schmerz. 2011. PMID: 21258822 Review. German. - Treatment of Persistent Idiopathic Dentoalveolar Pain with Venlafaxine: A Multicentric Retrospective Study on Its Effectiveness and Safety.
Xiao X, Chai G, Wang B, Luo F. Xiao X, et al. J Pain Res. 2023 Jul 21;16:2487-2495. doi: 10.2147/JPR.S420492. eCollection 2023. J Pain Res. 2023. PMID: 37497373 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical