Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome - PubMed (original) (raw)
Review
Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome
Boro Dropulic et al. Hum Gene Ther. 2006 Jun.
Abstract
More than 40 million people are infected with human immunodeficiency virus (HIV), and a successful vaccine is at least a decade away. Although highly active antiretroviral therapy prolongs life, the maintenance of viral latency requires life-long treatment and results in cumulative toxicities and viral escape mutants. Gene therapy offers the promise to cure or prevent progressive HIV infection by interfering with HIV replication and CD4+ cell decline long term in the absence of chronic chemotherapy, and approximately 2 million HIV-infected individuals live in settings where there is sufficient infrastructure to support its application with current technology. Although the development of HIV/AIDS gene therapy has been slow, progress in a number of areas is evident, so that studies to date have significantly advanced the field of gene-based immunotherapy. Advances have helped to define a series of ongoing and planned trials that may shed light on potential mechanisms for the successful clinical gene therapy of HIV.
Similar articles
- HIV immunotherapy comes of age: implications for prevention, treatment and cure.
Routy JP, Mehraj V, Cao W. Routy JP, et al. Expert Rev Clin Immunol. 2016;12(2):91-4. doi: 10.1586/1744666X.2016.1112269. Epub 2015 Dec 2. Expert Rev Clin Immunol. 2016. PMID: 26629806 - Immunopathogenesis and immunotherapy in AIDS virus infections.
Letvin NL, Walker BD. Letvin NL, et al. Nat Med. 2003 Jul;9(7):861-6. doi: 10.1038/nm0703-861. Nat Med. 2003. PMID: 12835706 Review. - Potential mechanisms for cell-based gene therapy to treat HIV/AIDS.
Herrera-Carrillo E, Berkhout B. Herrera-Carrillo E, et al. Expert Opin Ther Targets. 2015 Feb;19(2):245-63. doi: 10.1517/14728222.2014.980236. Epub 2014 Nov 12. Expert Opin Ther Targets. 2015. PMID: 25388088 Review. - Human immunodeficiency virus and acquired immunodeficiency syndrome: an update.
Schnittman SM, Fauci AS. Schnittman SM, et al. Adv Intern Med. 1994;39:305-55. Adv Intern Med. 1994. PMID: 8140958 Review. - Antitat gene therapy: a candidate for late-stage AIDS patients.
Lisziewicz J, Sun D, Lisziewicz A, Gallo RC. Lisziewicz J, et al. Gene Ther. 1995 May;2(3):218-22. Gene Ther. 1995. PMID: 7614253
Cited by
- Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.
Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, Zheng Z, Cotte J, Carpenito C, Wood T, Spratt SK, Ando D, Gregory P, Holmes MC, Perez EE, Riley JL, Carroll RG, June CH, Levine BL. Maier DA, et al. Hum Gene Ther. 2013 Mar;24(3):245-58. doi: 10.1089/hum.2012.172. Epub 2013 Mar 6. Hum Gene Ther. 2013. PMID: 23360514 Free PMC article. - Novel cell and gene therapies for HIV.
Hoxie JA, June CH. Hoxie JA, et al. Cold Spring Harb Perspect Med. 2012 Oct 1;2(10):a007179. doi: 10.1101/cshperspect.a007179. Cold Spring Harb Perspect Med. 2012. PMID: 23028130 Free PMC article. Review. - In vivo safety and persistence of endoribonuclease gene-transduced CD4+ T cells in cynomolgus macaques for HIV-1 gene therapy model.
Chono H, Saito N, Tsuda H, Shibata H, Ageyama N, Terao K, Yasutomi Y, Mineno J, Kato I. Chono H, et al. PLoS One. 2011;6(8):e23585. doi: 10.1371/journal.pone.0023585. Epub 2011 Aug 17. PLoS One. 2011. PMID: 21858176 Free PMC article. - Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection.
Kimpel J, Braun SE, Qiu G, Wong FE, Conolle M, Schmitz JE, Brendel C, Humeau LM, Dropulic B, Rossi JJ, Berger A, von Laer D, Johnson RP. Kimpel J, et al. PLoS One. 2010 Aug 23;5(8):e12357. doi: 10.1371/journal.pone.0012357. PLoS One. 2010. PMID: 20808813 Free PMC article. - The use of cell-delivered gene therapy for the treatment of HIV/AIDS.
Symonds GP, Johnstone HA, Millington ML, Boyd MP, Burke BP, Breton LR. Symonds GP, et al. Immunol Res. 2010 Dec;48(1-3):84-98. doi: 10.1007/s12026-010-8169-7. Immunol Res. 2010. PMID: 20737298 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials