Dynamic nuclear pore complexes: life on the edge - PubMed (original) (raw)
Review
. 2006 Jun 16;125(6):1041-53.
doi: 10.1016/j.cell.2006.05.027.
Affiliations
- PMID: 16777596
- DOI: 10.1016/j.cell.2006.05.027
Free article
Review
Dynamic nuclear pore complexes: life on the edge
Elizabeth J Tran et al. Cell. 2006.
Free article
Abstract
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. Altering the interactions between transport receptors and their cargo has been shown to be a major regulatory mechanism to control traffic through NPCs. New evidence now suggests that NPC proteins play active roles in translocation, and that transport is also controlled by dynamic changes in NPC composition and architecture. This view of ever-changing NPCs necessitates the re-evaluation of current models of nuclear transport and how this process is regulated.
Similar articles
- Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm.
Panté N, Kann M. Panté N, et al. Mol Biol Cell. 2002 Feb;13(2):425-34. doi: 10.1091/mbc.01-06-0308. Mol Biol Cell. 2002. PMID: 11854401 Free PMC article. - Regulation of nuclear transport: central role in development and transformation?
Poon IK, Jans DA. Poon IK, et al. Traffic. 2005 Mar;6(3):173-86. doi: 10.1111/j.1600-0854.2005.00268.x. Traffic. 2005. PMID: 15702986 Review. - New ways to skin a kap: mechanisms for controlling nuclear transport.
Lusk CP, Makhnevych T, Wozniak RW. Lusk CP, et al. Biochem Cell Biol. 2004 Dec;82(6):618-25. doi: 10.1139/o04-111. Biochem Cell Biol. 2004. PMID: 15674429 Review. - Dynamics of nuclear pore complex organization through the cell cycle.
Rabut G, Lénárt P, Ellenberg J. Rabut G, et al. Curr Opin Cell Biol. 2004 Jun;16(3):314-21. doi: 10.1016/j.ceb.2004.04.001. Curr Opin Cell Biol. 2004. PMID: 15145357 Review. - The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins.
Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. Walther TC, et al. EMBO J. 2001 Oct 15;20(20):5703-14. doi: 10.1093/emboj/20.20.5703. EMBO J. 2001. PMID: 11598013 Free PMC article.
Cited by
- Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways.
Huang WR, Chiu HC, Liao TL, Chuang KP, Shih WL, Liu HJ. Huang WR, et al. PLoS One. 2015 Aug 5;10(8):e0133699. doi: 10.1371/journal.pone.0133699. eCollection 2015. PLoS One. 2015. PMID: 26244501 Free PMC article. - B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis.
Hayashi D, Tanabe K, Katsube H, Inoue YH. Hayashi D, et al. Biol Open. 2016 Aug 15;5(8):1011-21. doi: 10.1242/bio.017566. Biol Open. 2016. PMID: 27402967 Free PMC article. - Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.
Sistla S, Pang JV, Wang CX, Balasundaram D. Sistla S, et al. Mol Biol Cell. 2007 Sep;18(9):3692-708. doi: 10.1091/mbc.e06-12-1062. Epub 2007 Jul 5. Mol Biol Cell. 2007. PMID: 17615301 Free PMC article. - NSP-interacting GTPase: A cytosolic protein as cofactor for nuclear shuttle proteins.
Carvalho CM, Machado JP, Zerbini FM, Fontes EP. Carvalho CM, et al. Plant Signal Behav. 2008 Sep;3(9):752-4. doi: 10.4161/psb.3.9.6641. Plant Signal Behav. 2008. PMID: 19704847 Free PMC article. - Arx1 is a nuclear export receptor for the 60S ribosomal subunit in yeast.
Hung NJ, Lo KY, Patel SS, Helmke K, Johnson AW. Hung NJ, et al. Mol Biol Cell. 2008 Feb;19(2):735-44. doi: 10.1091/mbc.e07-09-0968. Epub 2007 Dec 12. Mol Biol Cell. 2008. PMID: 18077551 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources