Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease - PubMed (original) (raw)
Review
. 2006 Jun;129(6):1673-82.
doi: 10.1378/chest.129.6.1673.
Affiliations
- PMID: 16778289
- DOI: 10.1378/chest.129.6.1673
Review
Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
R William Vandivier et al. Chest. 2006 Jun.
Abstract
Apoptosis and the removal of apoptotic cells (termed efferocytosis) are tightly coupled with the regulation of normal lung structure, both in the developing and adult organism. Processes that disrupt or uncouple this balance have the potential to alter normal cell turnover, ultimately resulting in the induction of lung pathology and disease. Apoptotic cells are increased in several chronic inflammatory lung diseases, including cystic fibrosis (CF), non-CF bronchiectasis, COPD, and asthma. While this may well be due to the enhanced induction of apoptosis, increasing data suggest that the clearance of dying cells is also impaired. Because efferocytosis appears to be a key regulatory checkpoint for the innate immune system, the adaptive immune system, and cell proliferation, the failure of this highly conserved process may contribute to disease pathogenesis by impeding both the resolution of inflammation and the maintenance of alveolar integrity. The recognition of impaired efferocytosis as a contributor to chronic inflammation may ultimately direct us toward the identification of new disease biomarkers, as well as novel therapeutic approaches.
Similar articles
- Efferocytosis and lung disease.
McCubbrey AL, Curtis JL. McCubbrey AL, et al. Chest. 2013 Jun;143(6):1750-1757. doi: 10.1378/chest.12-2413. Chest. 2013. PMID: 23732585 Free PMC article. Review. - Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Vandivier RW, et al. J Clin Invest. 2002 Mar;109(5):661-70. doi: 10.1172/JCI13572. J Clin Invest. 2002. PMID: 11877474 Free PMC article. - The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation.
Grabiec AM, Hussell T. Grabiec AM, et al. Semin Immunopathol. 2016 Jul;38(4):409-23. doi: 10.1007/s00281-016-0555-3. Epub 2016 Mar 8. Semin Immunopathol. 2016. PMID: 26957481 Free PMC article. Review. - Efferocytosis in health and disease.
Doran AC, Yurdagul A Jr, Tabas I. Doran AC, et al. Nat Rev Immunol. 2020 Apr;20(4):254-267. doi: 10.1038/s41577-019-0240-6. Epub 2019 Dec 10. Nat Rev Immunol. 2020. PMID: 31822793 Free PMC article. Review. - Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?
Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, Gibson P, Simpson JL, Buntain H, Chen ACH, Hodge G, Chang AB. Hodge S, et al. Chest. 2016 Feb;149(2):508-515. doi: 10.1016/j.chest.2015.10.066. Chest. 2016. PMID: 26867834
Cited by
- A novel molecular classification based on efferocytosis-related genes for predicting clinical outcome and treatment response in acute myeloid leukemia.
Zhong F, Yao F, Bai Q, Liu J, Li X, Huang B, Wang X. Zhong F, et al. Inflamm Res. 2024 Sep 2. doi: 10.1007/s00011-024-01938-w. Online ahead of print. Inflamm Res. 2024. PMID: 39223320 - The Respiratory Microbiome in Paediatric Chronic Wet Cough: What Is Known and Future Directions.
Atto B, Anteneh Y, Bialasiewicz S, Binks MJ, Hashemi M, Hill J, Thornton RB, Westaway J, Marsh RL. Atto B, et al. J Clin Med. 2023 Dec 28;13(1):171. doi: 10.3390/jcm13010171. J Clin Med. 2023. PMID: 38202177 Free PMC article. Review. - Inflammation-Associated Cytotoxic Agents in Tumorigenesis.
Arnhold J. Arnhold J. Cancers (Basel). 2023 Dec 22;16(1):81. doi: 10.3390/cancers16010081. Cancers (Basel). 2023. PMID: 38201509 Free PMC article. Review. - Effects of neutrophil fate on inflammation.
Xiao Y, Cheng Y, Liu WJ, Liu K, Wang Y, Xu F, Wang DM, Yang Y. Xiao Y, et al. Inflamm Res. 2023 Dec;72(12):2237-2248. doi: 10.1007/s00011-023-01811-2. Epub 2023 Nov 5. Inflamm Res. 2023. PMID: 37925664 Review. - The Role of Extracellular Vesicles in Efferocytosis.
Panahi S, Yazdi Z, Sanchouli M, Sajadi F, Motavasselian F, Maghareh Abed H, Beygi Z, Gheibihayat SM. Panahi S, et al. Mini Rev Med Chem. 2024;24(6):634-641. doi: 10.2174/0113895575247690230926113455. Mini Rev Med Chem. 2024. PMID: 37859308 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical