The co-evolution of host cationic antimicrobial peptides and microbial resistance - PubMed (original) (raw)

Review

doi: 10.1038/nrmicro1441. Epub 2006 Jun 12.

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• PMID: 16778838
• DOI: 10.1038/nrmicro1441

Review

The co-evolution of host cationic antimicrobial peptides and microbial resistance

Andreas Peschel et al. Nat Rev Microbiol. 2006 Jul.

Abstract

Endogenous cationic antimicrobial peptides (CAMPs) are among the most ancient and efficient components of host defence. It is somewhat of an enigma that bacteria have not developed highly effective CAMP-resistance mechanisms, such as those that inhibit many therapeutic antibiotics. Here, we propose that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host-pathogen balance that has shaped the existing CAMP repertoire. Elucidating the underlying principles of this process could help in the development of more sustainable antibiotics.

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