Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex - PubMed (original) (raw)
Comparative Study
. 2006 Jul 12;1099(1):101-8.
doi: 10.1016/j.brainres.2006.04.136. Epub 2006 Jun 19.
Affiliations
- PMID: 16784730
- DOI: 10.1016/j.brainres.2006.04.136
Comparative Study
Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex
Chris Pickering et al. Brain Res. 2006.
Abstract
Stress early in life puts the individual at a greater risk for developing mental disorders in adulthood. The animal model of maternal separation involves daily removal of pups from their mother over the early postnatal period and leads to several behavioral deficits in adults. Since this period corresponds to a time of extensive developmental changes in the glutamatergic system, glutamate receptor mRNA expression was studied in the hippocampus and prefrontal cortex. Male Wistar rats were either separated from their mother for 15 min (MS15 or 'handling') or 360 min (MS360) once a day from pnd 1-21 and glutamate receptor expression levels were measured at 25 weeks of age using real-time RT-PCR analysis. A third group of animal facility reared (AFR) rats was included as a control for the handling group. In the hippocampus, mRNA expression of NMDA NR2B and AMPA GluR1 and GluR2 receptors was significantly lower in MS360 rats relative to MS15. In addition, expression of the glutamate transporter GLAST was increased in MS360 relative to MS15. No differences were observed for AFR rats relative to MS15, which indicates that the hippocampal effects were not a result of handling or maternal care. For the prefrontal cortex, no difference in mRNA expression was observed for NMDA NR2A and NR2B or AMPA GluR1 and GluR2. These findings suggest that prolonged maternal separation produces neuroadaptive changes in the hippocampus that may, at least partially, account for the behavioral deficits previously observed in this animal model.
Similar articles
- Maternal separation alters acquisition of ethanol intake in male ethanol-preferring AA rats.
Roman E, Hyytiä P, Nylander I. Roman E, et al. Alcohol Clin Exp Res. 2003 Jan;27(1):31-7. doi: 10.1097/01.ALC.0000047352.88145.80. Alcohol Clin Exp Res. 2003. PMID: 12544002 - Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures.
Borbély S, Dobó E, Czégé D, Molnár E, Bakos M, Szucs B, Vincze A, Világi I, Mihály A. Borbély S, et al. Neuroscience. 2009 Mar 3;159(1):358-68. doi: 10.1016/j.neuroscience.2008.12.027. Epub 2008 Dec 27. Neuroscience. 2009. PMID: 19154779 - Time-dependent alterations in ethanol intake in male wistar rats exposed to short and prolonged daily maternal separation in a 4-bottle free-choice paradigm.
Gustafsson L, Nylander I. Gustafsson L, et al. Alcohol Clin Exp Res. 2006 Dec;30(12):2008-16. doi: 10.1111/j.1530-0277.2006.00247.x. Alcohol Clin Exp Res. 2006. PMID: 17117966 - Stress, depression, and inherited variation in primate hippocampal and prefrontal brain development.
Lyons DM. Lyons DM. Psychopharmacol Bull. 2002 Winter;36(1):27-43. Psychopharmacol Bull. 2002. PMID: 12397846 Review. - [Liver failure and neurotransmitters of central nervous system].
Fedosiewicz-Wasiluk M. Fedosiewicz-Wasiluk M. Pol Merkur Lekarski. 2002 Aug;13(74):151-3. Pol Merkur Lekarski. 2002. PMID: 12420350 Review. Polish.
Cited by
- Analysis of hippocampal synaptic function in a rodent model of early life stress.
Wilkinson MP, Robinson ESJ, Mellor JR. Wilkinson MP, et al. Wellcome Open Res. 2024 Jun 10;9:300. doi: 10.12688/wellcomeopenres.22276.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39221440 Free PMC article. - Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist.
Ladagu AD, Olopade FE, Chazot P, Oyagbemi AA, Ohiomokhare S, Folarin OR, Gilbert TT, Fuller M, Luong T, Adejare A, Olopade JO. Ladagu AD, et al. Int J Mol Sci. 2023 Nov 24;24(23):16710. doi: 10.3390/ijms242316710. Int J Mol Sci. 2023. PMID: 38069032 Free PMC article. - Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor.
Filarowska-Jurko J, Komsta L, Smaga I, Surowka P, Marszalek-Grabska M, Grochecki P, Nizio D, Filip M, Kotlinska JH. Filarowska-Jurko J, et al. Int J Mol Sci. 2022 May 11;23(10):5350. doi: 10.3390/ijms23105350. Int J Mol Sci. 2022. PMID: 35628160 Free PMC article. - Role of NMDA Receptors in Adult Neurogenesis and Normal Development of the Dentate Gyrus.
Åmellem I, Yovianto G, Chong HT, Nair RR, Cnops V, Thanawalla A, Tashiro 田代 歩 A. Åmellem I, et al. eNeuro. 2021 Aug 5;8(4):ENEURO.0566-20.2021. doi: 10.1523/ENEURO.0566-20.2021. Print 2021 Jul-Aug. eNeuro. 2021. PMID: 34266965 Free PMC article. - Behavioral and Neurodevelopmental Effects of Early Interventions in Adult Wistar Rats.
Küçükkarapinar M, Dönmez A, Candansayar S, Bozkurt A, Akçay E, Gülbahar Ö, Belen HB. Küçükkarapinar M, et al. Noro Psikiyatr Ars. 2021 Jun 3;58(2):137-145. doi: 10.29399/npa.24943. eCollection 2021 Jun. Noro Psikiyatr Ars. 2021. PMID: 34188597 Free PMC article.