Thymic stromal lymphopoietin in normal and pathogenic T cell development and function - PubMed (original) (raw)
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doi: 10.1038/ni1360.
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- PMID: 16785889
- DOI: 10.1038/ni1360
Review
Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
Steven F Ziegler et al. Nat Immunol. 2006 Jul.
Abstract
Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell-mediated allergic inflammation.
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