Nucleophosmin and cancer - PubMed (original) (raw)
Review
doi: 10.1038/nrc1885.
Affiliations
- PMID: 16794633
- DOI: 10.1038/nrc1885
Review
Nucleophosmin and cancer
Silvia Grisendi et al. Nat Rev Cancer. 2006 Jul.
Abstract
NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis.
Similar articles
- Role of nucleophosmin in embryonic development and tumorigenesis.
Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K, Pandolfi PP. Grisendi S, et al. Nature. 2005 Sep 1;437(7055):147-53. doi: 10.1038/nature03915. Epub 2005 Jul 6. Nature. 2005. PMID: 16007073 - Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers.
Jeong EG, Lee SH, Yoo NJ, Lee SH. Jeong EG, et al. APMIS. 2007 Apr;115(4):341-6. doi: 10.1111/j.1600-0463.2007.apm_592.x. APMIS. 2007. PMID: 17504301 - Nucleophosmin: from structure and function to disease development.
Box JK, Paquet N, Adams MN, Boucher D, Bolderson E, O'Byrne KJ, Richard DJ. Box JK, et al. BMC Mol Biol. 2016 Aug 24;17(1):19. doi: 10.1186/s12867-016-0073-9. BMC Mol Biol. 2016. PMID: 27553022 Free PMC article. Review. - The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.
Cheng K, Grisendi S, Clohessy JG, Majid S, Bernardi R, Sportoletti P, Pandolfi PP. Cheng K, et al. Oncogene. 2007 Nov 22;26(53):7391-400. doi: 10.1038/sj.onc.1210549. Epub 2007 Jun 4. Oncogene. 2007. PMID: 17546053 - Role of nucleophosmin in acute myeloid leukemia.
Meani N, Alcalay M. Meani N, et al. Expert Rev Anticancer Ther. 2009 Sep;9(9):1283-94. doi: 10.1586/era.09.84. Expert Rev Anticancer Ther. 2009. PMID: 19761432 Review.
Cited by
- Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway.
Fuchs O. Fuchs O. Leuk Res Treatment. 2012;2012:179402. doi: 10.1155/2012/179402. Epub 2012 Feb 13. Leuk Res Treatment. 2012. PMID: 23213547 Free PMC article. - The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription.
Katagiri N, Kuroda T, Kishimoto H, Hayashi Y, Kumazawa T, Kimura K. Katagiri N, et al. Sci Rep. 2015 Mar 10;5:8903. doi: 10.1038/srep08903. Sci Rep. 2015. PMID: 25754892 Free PMC article. - Molecules that target nucleophosmin for cancer treatment: an update.
Di Matteo A, Franceschini M, Chiarella S, Rocchio S, Travaglini-Allocatelli C, Federici L. Di Matteo A, et al. Oncotarget. 2016 Jul 12;7(28):44821-44840. doi: 10.18632/oncotarget.8599. Oncotarget. 2016. PMID: 27058426 Free PMC article. Review. - Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.
Wang F, Chan LW, Tsui NB, Wong SC, Siu PM, Yip SP, Yung BY. Wang F, et al. Biomed Res Int. 2015;2015:610595. doi: 10.1155/2015/610595. Epub 2015 Apr 15. Biomed Res Int. 2015. PMID: 25961029 Free PMC article. - Infrequent Presentations of Chronic _NPM1_-Mutated Myeloid Neoplasms: Clinicopathological Features of Eight Cases from a Single Institution and Review of the Literature.
Castaño-Díez S, Guijarro F, López-Guerra M, Pérez-Valencia AI, Gómez-Núñez M, Colomer D, Díaz-Beyá M, Esteve J, Rozman M. Castaño-Díez S, et al. Cancers (Basel). 2024 Feb 7;16(4):705. doi: 10.3390/cancers16040705. Cancers (Basel). 2024. PMID: 38398096 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources