A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation - PubMed (original) (raw)

Comparative Study

. 1991 Sep;139(3):589-98.

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Comparative Study

A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation

M Miyazono et al. Am J Pathol. 1991 Sep.

Abstract

The authors examined 10 patients with Gerstmann-Sträussler syndrome or Creutzfeldt-Jakob disease and 10 with Alzheimer's disease (AD). Immunohistochemistry using anti-prion protein (PrP) and anti-beta/A4 protein (beta/A4) coupled with formic acid pretreatment could detect Congophilic and non-Congophilic deposits. Prion protein deposits were classified into five types and compared with types of beta/A4 deposits. Kuru plaques with multicentric cores and fine granular deposits were a characteristic feature of PrP deposits. Some types of PrP or beta/A4 deposits depend on the anatomic sites. To clarify the relationship of microglia and astrocytes to PrP or beta/A4 deposits, double-immunostaining method was performed. In both kuru and senile plaques, microglia were closely linked to the Congophilic plaques. Astrocytes, however, extended their processes toward the plaques even in the non-Congophilic plaques. These observations strongly suggest that similar glial association with plaque formation may be involved in both kuru and senile plaques, although the amyloid core proteins differ.

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References

    1. J Histochem Cytochem. 1979 Aug;27(8):1131-9 - PubMed
    1. Ann Neurol. 1979 Jun;5(6):581-4 - PubMed
    1. Arch Neurol. 1962 Feb;6:114-22 - PubMed
    1. Acta Neuropathol. 1991;81(3):242-7 - PubMed
    1. Brain Pathol. 1990 Sep;1(1):2-5 - PubMed

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