Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging - PubMed (original) (raw)
Comparative Study
Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging
Peifeng Hu et al. J Gerontol A Biol Sci Med Sci. 2006 Jun.
Abstract
Background: Growing evidence from animal studies suggests an interaction between antioxidants and apolipoprotein E (APOE) alleles on cognitive functioning. We used data from a 7-year cohort study of high-functioning older persons to explore whether the associations between serum beta-carotene level and subsequent decline of cognitive function differed by APOE 4 genotype.
Methods: Baseline information on sociodemographic characteristics, serum beta-carotene level, inflammation markers, APOE genotype, and cognitive functioning measured by a 9-item Short Portable Mental Status Questionnaire (SPMSQ) was obtained in 455 survivors. Multivariable logistic regression analyses were used to examine the relation between high serum beta-carotene level and risk of SPMSQ score decline in participants with or without APOE 4 alleles, while adjusting for age, sex, race, baseline SPMSQ score, and other covariates.
Results: Nine (2%) study participants had homozygous and 97 (21%) had heterozygous APOE 4 alleles. Two hundred forty-nine (55%) had decline of SPMSQ scores during the follow-up. The presence of an APOE 4 allele was associated with higher risk and larger magnitude of SPMSQ score decline. The adjusted odds ratio of high beta-carotene level for cognitive decline was 0.11 (95% confidence interval, 0.02-0.57) in participants with at least one APOE 4 allele and 0.89 (95% confidence interval, 0.54-1.47) among those who were APOE 4 negative.
Conclusion: Among high-functioning older persons, antioxidants and beta-carotene in particular may offer protection from cognitive decline in persons with greater genetic susceptibility as evidenced by the presence of the APOE 4 allele.
Similar articles
- The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents.
Fillenbaum GG, Landerman LR, Blazer DG, Saunders AM, Harris TB, Launer LJ. Fillenbaum GG, et al. J Am Geriatr Soc. 2001 Sep;49(9):1148-55. doi: 10.1046/j.1532-5415.2001.49230.x. J Am Geriatr Soc. 2001. PMID: 11559372 - The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons.
Haan MN, Shemanski L, Jagust WJ, Manolio TA, Kuller L. Haan MN, et al. JAMA. 1999 Jul 7;282(1):40-6. doi: 10.1001/jama.282.1.40. JAMA. 1999. PMID: 10404910 - The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.
Bretsky P, Guralnik JM, Launer L, Albert M, Seeman TE; MacArthur Studies of Successful Aging. Bretsky P, et al. Neurology. 2003 Apr 8;60(7):1077-81. doi: 10.1212/01.wnl.0000055875.26908.24. Neurology. 2003. PMID: 12682309 - Cerebrovascular disease, APOE epsilon4 allele and cognitive decline in a cognitively normal population.
Qiu C, Winblad B, Fratiglioni L. Qiu C, et al. Neurol Res. 2006 Sep;28(6):650-6. doi: 10.1179/016164106X130443. Neurol Res. 2006. PMID: 16945218 - Apolipoproteins and aging: emerging mechanisms.
Smith JD. Smith JD. Ageing Res Rev. 2002 Jun;1(3):345-65. doi: 10.1016/s1568-1637(02)00005-3. Ageing Res Rev. 2002. PMID: 12067591 Review.
Cited by
- Recent advances in research on successful or healthy aging.
Depp CA, Glatt SJ, Jeste DV. Depp CA, et al. Curr Psychiatry Rep. 2007 Feb;9(1):7-13. doi: 10.1007/s11920-007-0003-0. Curr Psychiatry Rep. 2007. PMID: 17257507 Review. - Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.
Barberger-Gateau P, Samieri C, Féart C, Plourde M. Barberger-Gateau P, et al. Curr Alzheimer Res. 2011 Aug;8(5):479-91. doi: 10.2174/156720511796391926. Curr Alzheimer Res. 2011. PMID: 21605054 Free PMC article. Review. - Reactive oxygen species in the regulation of synaptic plasticity and memory.
Massaad CA, Klann E. Massaad CA, et al. Antioxid Redox Signal. 2011 May 15;14(10):2013-54. doi: 10.1089/ars.2010.3208. Epub 2010 Oct 28. Antioxid Redox Signal. 2011. PMID: 20649473 Free PMC article. Review. - Detecting cognitive decline in high-functioning older adults: The relationship between subjective cognitive concerns, frequency of high neuropsychological test scores, and the frontoparietal control network.
Karr JE, Hakun JG, Elbich DB, Pinheiro CN, Schmitt FA, Segerstrom SC. Karr JE, et al. J Int Neuropsychol Soc. 2024 Mar;30(3):220-231. doi: 10.1017/S1355617723000607. Epub 2023 Sep 26. J Int Neuropsychol Soc. 2024. PMID: 37750195 Free PMC article. - Supplementation of adult rats with moderate amounts of β-carotene modulates the redox status in plasma without exerting pro-oxidant effects in the brain: a safer alternative to food fortification with vitamin A?
Schnorr CE, Morrone Mda S, Simões-Pires A, Bittencourt Lda S, Zeidán-Chuliá F, Moreira JC. Schnorr CE, et al. Nutrients. 2014 Dec 1;6(12):5572-82. doi: 10.3390/nu6125572. Nutrients. 2014. PMID: 25470379 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous