A controlled trial of homocysteine lowering and cognitive performance - PubMed (original) (raw)
Randomized Controlled Trial
. 2006 Jun 29;354(26):2764-72.
doi: 10.1056/NEJMoa054025.
Affiliations
- PMID: 16807413
- DOI: 10.1056/NEJMoa054025
Free article
Randomized Controlled Trial
A controlled trial of homocysteine lowering and cognitive performance
Jennifer A McMahon et al. N Engl J Med. 2006.
Free article
Abstract
Background: The results of observational studies suggest that plasma homocysteine concentrations are inversely related to cognitive function in older people. Our objective was to test the hypothesis that lowering the plasma homocysteine concentration improves cognitive function in healthy older people.
Methods: We conducted a two-year, double-blind, placebo-controlled, randomized clinical trial involving 276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations of at least 13 micromol per liter. Homocysteine-lowering treatment was a daily supplement containing folate (1000 microg) and vitamins B12 (500 microg) and B6 (10 mg). Tests of cognition were conducted at baseline and after one and two years of treatment. Treatment effects were adjusted for baseline values, sex, and education.
Results: On average, during the course of the study, the plasma homocysteine concentration was 4.36 micromol per liter (95 percent confidence interval, 3.81 to 4.91 micromol per liter) lower in the vitamin group than in the placebo group (P<0.001). Overall, there were no significant differences between the vitamin and placebo groups in the scores on tests of cognition.
Conclusions: The results of this trial do not support the hypothesis that homocysteine lowering with B vitamins improves cognitive performance. (Australian Clinical Trials registry number, ACTR NO 12605000030673.).
Copyright 2006 Massachusetts Medical Society.
Comment in
- Vitamin B12, folic acid, and the prevention of dementia.
Clarke R. Clarke R. N Engl J Med. 2006 Jun 29;354(26):2817-9. doi: 10.1056/NEJMe068086. N Engl J Med. 2006. PMID: 16807420 No abstract available. - Homocysteine lowering and cognitive performance.
Lucca U, Tettamanti M, Quadri P. Lucca U, et al. N Engl J Med. 2006 Sep 28;355(13):1390; author reply 1391. doi: 10.1056/NEJMc062011. N Engl J Med. 2006. PMID: 17005963 No abstract available. - Homocysteine lowering and cognitive performance.
Dettling M, Opgen-Rhein C, Anghelescu IG. Dettling M, et al. N Engl J Med. 2006 Sep 28;355(13):1390; author reply 1391. N Engl J Med. 2006. PMID: 17014040 No abstract available. - Homocysteine lowering and cognitive performance.
Narayan RL. Narayan RL. N Engl J Med. 2006 Sep 28;355(13):1390-1; author reply 1391. N Engl J Med. 2006. PMID: 17014041 No abstract available. - Homocysteine-lowering vitamin B supplements do not improve cognitive performance in healthy older adults after two years.
Clarke R. Clarke R. Evid Based Ment Health. 2007 Feb;10(1):27. doi: 10.1136/ebmh.10.1.27. Evid Based Ment Health. 2007. PMID: 17255396 No abstract available.
Similar articles
- Homocysteine lowering and cognitive performance.
Dettling M, Opgen-Rhein C, Anghelescu IG. Dettling M, et al. N Engl J Med. 2006 Sep 28;355(13):1390; author reply 1391. N Engl J Med. 2006. PMID: 17014040 No abstract available. - Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial.
de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. de Jager CA, et al. Int J Geriatr Psychiatry. 2012 Jun;27(6):592-600. doi: 10.1002/gps.2758. Epub 2011 Jul 21. Int J Geriatr Psychiatry. 2012. PMID: 21780182 Clinical Trial. - Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements.
Clarke R, Armitage J. Clarke R, et al. Semin Thromb Hemost. 2000;26(3):341-8. doi: 10.1055/s-2000-8101. Semin Thromb Hemost. 2000. PMID: 11011852 Review. - Vitamins B(12), B(6), and folic acid for cognition in older men.
Ford AH, Flicker L, Alfonso H, Thomas J, Clarnette R, Martins R, Almeida OP. Ford AH, et al. Neurology. 2010 Oct 26;75(17):1540-7. doi: 10.1212/WNL.0b013e3181f962c4. Epub 2010 Sep 22. Neurology. 2010. PMID: 20861451 Clinical Trial. - Folic acid with or without vitamin B12 for cognition and dementia.
Malouf M, Grimley EJ, Areosa SA. Malouf M, et al. Cochrane Database Syst Rev. 2003;(4):CD004514. doi: 10.1002/14651858.CD004514. Cochrane Database Syst Rev. 2003. PMID: 14584018 Updated. Review.
Cited by
- Relationship between serum levels of folic acid and homocysteine with cognitive impairment in patients diagnosed with multiple sclerosis.
Imeni Kashan A, Mirzaasgari Z, Nouri Shirazi S. Imeni Kashan A, et al. Medicine (Baltimore). 2024 Jul 12;103(28):e38680. doi: 10.1097/MD.0000000000038680. Medicine (Baltimore). 2024. PMID: 38996106 Free PMC article. - Does folic acid supplementation have a positive effect on improving memory? A systematic review and meta-analysis of randomized controlled trials.
Akhgarjand C, Ebrahimi Mousavi S, Kalantar Z, Bagheri A, Imani H, Rezvani H, Ghorbi MD, Vahabi Z. Akhgarjand C, et al. Front Aging Neurosci. 2022 Nov 28;14:966933. doi: 10.3389/fnagi.2022.966933. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36518821 Free PMC article. - The effect of vitamin B supplementation on neuronal injury in people living with HIV: a randomized controlled trial.
Tyrberg E, Hagberg L, Andersson LM, Nilsson S, Yilmaz A, Mellgren Å, Blennow K, Zetterberg H, Gisslén M. Tyrberg E, et al. Brain Commun. 2022 Oct 15;4(6):fcac259. doi: 10.1093/braincomms/fcac259. eCollection 2022. Brain Commun. 2022. PMID: 36337345 Free PMC article. - Efficacy of comprehensive cognitive health management for Shanghai community older adults with mild cognitive impairment.
Qiu J, Zhao L, Xiao S, Zhang S, Li L, Nie J, Bai L, Qian S, Yang Y, Phillips M, Sheng M, Fang Y, Li X. Qiu J, et al. Gen Psychiatr. 2022 Aug 25;35(4):e100532. doi: 10.1136/gpsych-2021-100532. eCollection 2022. Gen Psychiatr. 2022. PMID: 36118417 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical