Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma - PubMed (original) (raw)
Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma
A C Wotherspoon et al. Lancet. 1991.
Abstract
Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori, and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pylori infection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.
Comment in
- Helicobacter pylori gastritis and gastric MALT-lymphoma.
Stolte M. Stolte M. Lancet. 1992 Mar 21;339(8795):745-6. doi: 10.1016/0140-6736(92)90645-j. Lancet. 1992. PMID: 1347613 No abstract available. - H pylori, gastric carcinoma, and MALT lymphoma.
Kelly SM, Geraghty JM, Neale G. Kelly SM, et al. Lancet. 1994 Feb 12;343(8894):418. doi: 10.1016/s0140-6736(94)91254-8. Lancet. 1994. PMID: 7905571 No abstract available. - Relapse of MALT lymphoma associated with Helicobacter pylori after antibiotic treatment.
Horstmann M, Erttmann R, Winkler K. Horstmann M, et al. Lancet. 1994 Apr 30;343(8905):1098-9. doi: 10.1016/s0140-6736(94)90208-9. Lancet. 1994. PMID: 7909113 No abstract available.
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