Predictive capacity of pre-donation GFR and renal reserve capacity for donor renal function after living kidney donation - PubMed (original) (raw)
Predictive capacity of pre-donation GFR and renal reserve capacity for donor renal function after living kidney donation
M Rook et al. Am J Transplant. 2006 Jul.
Free article
Abstract
Kidney transplantation from living donors is important to reduce organ shortage. Reliable pre-operative estimation of post-donation renal function is essential. We evaluated the predictive potential of pre-donation glomerular filtration rate (GFR) (iothalamate) and renal reserve capacity for post-donation GFR in kidney donors. GFR was measured in 125 consecutive donors (age 49 +/- 11 years; 36% male) 119 +/- 99 days before baseline GFR (GFRb) and 57 +/- 16 days after donation (GFRpost). Reserve capacity was assessed as GFR during stimulation by low-dose dopamine (GFRdopa), amino acids (GFRAA) and both (GFRmax). GFRb was 112 +/- 18, GFRdopa 124 +/- 22, GFRAA 127 +/- 19 and GFRmax 138 +/- 22 mL/min. After donation, GFR remained 64 +/- 7%. GFRpost was predicted by GFRb(R2 = 0.54), GFRdopa(R2 = 0.35), GFRAA(R2 = 0.56), GFRmax(R2 = 0.55)and age (R2 = -0.22; p < 0.001 for all). Linear regression provided the equation GFRpost = 20.01 + (0.46*GFRb). Multivariate analysis predicted GFRpost by GFRb, age and GFRmax(R2 = 0.61, p < 0.001). Post-donation renal function impairment (GFR < or = 60 mL/min/1.73 m2) occurred in 31 donors. On logistic regression, GFRb, body mass index (BMI) and age were independent predictors for renal function impairment, without added value of reserve capacity. GFR allows a relatively reliable prediction of post-donation GFR, improving by taking age and stimulated GFR into account. Long-term studies are needed to further assess the prognostic value of pre-donation characteristics and to prospectively identify subjects with higher risk for renal function loss.
Similar articles
- Renal functional reserve capacity before and after living kidney donation.
van Londen M, Kasper N, Hessels NR, Messchendorp AL, Bakker SJL, Sanders JS, Berger SP, de Borst MH, Navis G. van Londen M, et al. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1550-F1554. doi: 10.1152/ajprenal.00064.2018. Epub 2018 Aug 8. Am J Physiol Renal Physiol. 2018. PMID: 30089036 - Nephrectomy elicits impact of age and BMI on renal hemodynamics: lower postdonation reserve capacity in older or overweight kidney donors.
Rook M, Bosma RJ, van Son WJ, Hofker HS, van der Heide JJ, ter Wee PM, Ploeg RJ, Navis GJ. Rook M, et al. Am J Transplant. 2008 Oct;8(10):2077-85. doi: 10.1111/j.1600-6143.2008.02355.x. Epub 2008 Jul 22. Am J Transplant. 2008. PMID: 18727700 - [Long term renal function outcomes and predictive factors of chronic renal failure after living kidney donation].
Sichez PC, Baboudjian M, Depalorte V, Karsenty G, Lechevallier É, Boissier R. Sichez PC, et al. Prog Urol. 2019 Sep;29(10):496-503. doi: 10.1016/j.purol.2019.07.003. Epub 2019 Aug 2. Prog Urol. 2019. PMID: 31383507 French. - GFR Assessment of Living Kidney Donors Candidates.
Gaillard F, Legendre C, White CA. Gaillard F, et al. Transplantation. 2019 Jun;103(6):1086-1093. doi: 10.1097/TP.0000000000002620. Transplantation. 2019. PMID: 30801521 Review. - Proteinuria and reduced kidney function in living kidney donors: A systematic review, meta-analysis, and meta-regression.
Garg AX, Muirhead N, Knoll G, Yang RC, Prasad GV, Thiessen-Philbrook H, Rosas-Arellano MP, Housawi A, Boudville N; Donor Nephrectomy Outcomes Research (DONOR) Network. Garg AX, et al. Kidney Int. 2006 Nov;70(10):1801-10. doi: 10.1038/sj.ki.5001819. Epub 2006 Sep 27. Kidney Int. 2006. PMID: 17003822 Review.
Cited by
- Prediction of measured GFR after living kidney donation from pre-donation parameters.
van Londen M, van der Weijden J, Niznik RS, Mullan AF, Bakker SJL, Berger SP, Nolte IM, Sanders JF, Navis G, Rule AD, de Borst MH. van Londen M, et al. Nephrol Dial Transplant. 2023 Jan 23;38(1):212-221. doi: 10.1093/ndt/gfac202. Nephrol Dial Transplant. 2023. PMID: 35731584 Free PMC article. - How Does the Remaining Single Kidney Cope After Contralateral Nephrectomy of the Kidney Donor? A Single-Center Cohort Study.
Altheaby A, Alharbi N, Alzamil A, Alzahrani E, Alshaia AM, Aldowsary B, Aboalsamah G, Farooqui M, Bin Saad K, Arabi Z. Altheaby A, et al. Cureus. 2020 Nov 15;12(11):e11491. doi: 10.7759/cureus.11491. Cureus. 2020. PMID: 33335820 Free PMC article. - Acute kidney injury in renal transplant recipients undergoing cardiac surgery.
Hundemer GL, Srivastava A, Jacob KA, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel KK, Hirji SA, Pelletier M, Safa K, Kulvichit W, Kellum JA, Riella LV, Leaf DE. Hundemer GL, et al. Nephrol Dial Transplant. 2021 Jan 1;36(1):185-196. doi: 10.1093/ndt/gfaa063. Nephrol Dial Transplant. 2021. PMID: 32892219 Free PMC article. - Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities.
Stevens LA, Claybon MA, Schmid CH, Chen J, Horio M, Imai E, Nelson RG, Van Deventer M, Wang HY, Zuo L, Zhang YL, Levey AS. Stevens LA, et al. Kidney Int. 2011 Mar;79(5):555-62. doi: 10.1038/ki.2010.462. Epub 2010 Nov 24. Kidney Int. 2011. PMID: 21107446 Free PMC article. - Renal function equations before and after living kidney donation: a within-individual comparison of performance at different levels of renal function.
Tent H, Rook M, Stevens LA, van Son WJ, van Pelt LJ, Hofker HS, Ploeg RJ, van der Heide JJ, Navis G. Tent H, et al. Clin J Am Soc Nephrol. 2010 Nov;5(11):1960-8. doi: 10.2215/CJN.08761209. Epub 2010 Jul 8. Clin J Am Soc Nephrol. 2010. PMID: 20616162 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical