Antigenic diversity thresholds and the development of AIDS - PubMed (original) (raw)
. 1991 Nov 15;254(5034):963-9.
doi: 10.1126/science.1683006.
Affiliations
- PMID: 1683006
- DOI: 10.1126/science.1683006
Antigenic diversity thresholds and the development of AIDS
M A Nowak et al. Science. 1991.
Abstract
Longitudinal studies of patients infected with HIV-1 reveal a long and variable incubation period between infection and the development of AIDS. Data from a small number of infected patients show temporal changes in the number of genetically distinct strains of the virus throughout the incubation period, with a slow but steady rise in diversity during the progression to disease. A mathematical model of the dynamic interaction between viral diversity and the human immune system suggests the existence of an antigen diversity threshold, below which the immune system is able to regulate viral population growth but above which the virus population induces the collapse of the CD4+ lymphocyte population. The model suggests that antigenic diversity is the cause, not a consequence, of immunodeficiency disease. The model is compared with available data, and is used to assess how the timing of the application of chemotherapy or immunotherapy influences the rate of progress to disease.
Comment in
- AIDS: the evolution of an infection.
Palca J. Palca J. Science. 1991 Nov 15;254(5034):941. doi: 10.1126/science.1948079. Science. 1991. PMID: 1948079 No abstract available.
Similar articles
- The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease.
Nowak MA, May RM, Anderson RM. Nowak MA, et al. AIDS. 1990 Nov;4(11):1095-103. doi: 10.1097/00002030-199011000-00007. AIDS. 1990. PMID: 2282182 - Detection of infectious immune complexes in human immunodeficiency virus type 1 (HIV-1) infections: correlation with plasma viremia and CD4 cell counts.
Fiscus SA, Wallmark EB, Folds JD, Fryer J, van der Horst CM. Fiscus SA, et al. J Infect Dis. 1991 Oct;164(4):765-9. doi: 10.1093/infdis/164.4.765. J Infect Dis. 1991. PMID: 1680137 - AIDS pathogenesis: a finite immune response to blame?
Miedema F, Klein MR. Miedema F, et al. Science. 1996 Apr 26;272(5261):505-6. doi: 10.1126/science.272.5261.505. Science. 1996. PMID: 8614796 Review. No abstract available. - A mathematical model of vaccination against HIV to prevent the development of AIDS.
Nowak MA, McLean AR. Nowak MA, et al. Proc Biol Sci. 1991 Nov 22;246(1316):141-6. doi: 10.1098/rspb.1991.0136. Proc Biol Sci. 1991. PMID: 1685238 - Genotypic and phenotypic variation of HIV-1: impact on AIDS pathogenesis and vaccination.
Wolfs TF, Nara PL, Goudsmit J. Wolfs TF, et al. Chem Immunol. 1993;56:1-33. Chem Immunol. 1993. PMID: 8383980 Review. No abstract available.
Cited by
- Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient.
Holmes EC, Zhang LQ, Simmonds P, Ludlam CA, Brown AJ. Holmes EC, et al. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4835-9. doi: 10.1073/pnas.89.11.4835. Proc Natl Acad Sci U S A. 1992. PMID: 1594583 Free PMC article. - Evolutionary dynamics of HIV at multiple spatial and temporal scales.
Hill AL, Rosenbloom DI, Nowak MA. Hill AL, et al. J Mol Med (Berl). 2012 May;90(5):543-61. doi: 10.1007/s00109-012-0892-1. Epub 2012 May 3. J Mol Med (Berl). 2012. PMID: 22552382 Free PMC article. Review. - The fastest evolutionary trajectory.
Traulsen A, Iwasa Y, Nowak MA. Traulsen A, et al. J Theor Biol. 2007 Dec 7;249(3):617-23. doi: 10.1016/j.jtbi.2007.08.012. Epub 2007 Aug 28. J Theor Biol. 2007. PMID: 17900629 Free PMC article. - Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDS.
Wodarz D, Levy DN. Wodarz D, et al. Proc Biol Sci. 2007 Oct 7;274(1624):2481-90. doi: 10.1098/rspb.2007.0413. Proc Biol Sci. 2007. PMID: 17666377 Free PMC article. - Immunological Paradigms, Mechanisms, and Models: Conceptual Understanding Is a Prerequisite to Effective Modeling.
Grossman Z. Grossman Z. Front Immunol. 2019 Nov 5;10:2522. doi: 10.3389/fimmu.2019.02522. eCollection 2019. Front Immunol. 2019. PMID: 31749803 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials