Molecular mechanism of the life and death of the osteoclast - PubMed (original) (raw)

Review

doi: 10.1196/annals.1346.020.

Tsuyoshi Miyazaki, Akira Fukuda, Toru Akiyama, Yuho Kadono, Hidetoshi Wakeyama, Shinjiro Kono, Shinya Hoshikawa, Masaki Nakamura, Yasushi Ohshima, Atsuhiko Hikita, Ichiro Nakamura, Kozo Nakamura

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Review

Molecular mechanism of the life and death of the osteoclast

Sakae Tanaka et al. Ann N Y Acad Sci. 2006 Apr.

Abstract

The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.

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