Molecular mechanism of the life and death of the osteoclast - PubMed (original) (raw)
Review
doi: 10.1196/annals.1346.020.
Tsuyoshi Miyazaki, Akira Fukuda, Toru Akiyama, Yuho Kadono, Hidetoshi Wakeyama, Shinjiro Kono, Shinya Hoshikawa, Masaki Nakamura, Yasushi Ohshima, Atsuhiko Hikita, Ichiro Nakamura, Kozo Nakamura
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- PMID: 16831917
- DOI: 10.1196/annals.1346.020
Review
Molecular mechanism of the life and death of the osteoclast
Sakae Tanaka et al. Ann N Y Acad Sci. 2006 Apr.
Abstract
The life span of osteoclasts is critically regulated by various cytokines, and therapeutics such as bisphosphonates act directly on osteoclasts and induce apoptosis of the cells. This article will focus on the molecular mechanism of osteoclast apoptosis and summarize the recent advances in this field with an emphasis on the role of intracellular signaling pathways.
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