The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats - PubMed (original) (raw)

Comparative Study

. 2006 Oct 2;173(1):148-52.

doi: 10.1016/j.bbr.2006.06.008. Epub 2006 Jul 10.

Affiliations

• PMID: 16834996
• DOI: 10.1016/j.bbr.2006.06.008

Comparative Study

The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats

Jennifer M Bossert et al. Behav Brain Res. 2006.

Abstract

We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context- and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking.

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