Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands - PubMed (original) (raw)
Review
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands
Lai-Hua Xie et al. Prog Biophys Mol Biol. 2007 Jul.
Free article
Abstract
All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP(2)). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (K(ATP)) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na(+) ions. Recent studies have demonstrated that PIP(2) acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP(2) and co-factors modulate channel activities in each subfamily of the Kir channels.
Similar articles
- Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.
Logothetis DE, Jin T, Lupyan D, Rosenhouse-Dantsker A. Logothetis DE, et al. Pflugers Arch. 2007 Oct;455(1):83-95. doi: 10.1007/s00424-007-0276-5. Epub 2007 May 23. Pflugers Arch. 2007. PMID: 17520276 Review. - Review on regulation of inwardly rectifying potassium channels.
Wang J, Huang Y, Ning Q. Wang J, et al. Crit Rev Eukaryot Gene Expr. 2011;21(4):303-11. doi: 10.1615/critreveukargeneexpr.v21.i4.10. Crit Rev Eukaryot Gene Expr. 2011. PMID: 22181700 Review. - PIP2--the master key.
Guy-David L, Reuveny E. Guy-David L, et al. Neuron. 2007 Aug 16;55(4):537-8. doi: 10.1016/j.neuron.2007.08.001. Neuron. 2007. PMID: 17698006 - Inwardly rectifying potassium channels: their structure, function, and physiological roles.
Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y. Hibino H, et al. Physiol Rev. 2010 Jan;90(1):291-366. doi: 10.1152/physrev.00021.2009. Physiol Rev. 2010. PMID: 20086079 Review. - Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.
Loussouarn G, Park KH, Bellocq C, Baró I, Charpentier F, Escande D. Loussouarn G, et al. EMBO J. 2003 Oct 15;22(20):5412-21. doi: 10.1093/emboj/cdg526. EMBO J. 2003. PMID: 14532114 Free PMC article.
Cited by
- Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.
Logothetis DE, Jin T, Lupyan D, Rosenhouse-Dantsker A. Logothetis DE, et al. Pflugers Arch. 2007 Oct;455(1):83-95. doi: 10.1007/s00424-007-0276-5. Epub 2007 May 23. Pflugers Arch. 2007. PMID: 17520276 Review. - Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2.
Meng XY, Kang SG, Zhou R. Meng XY, et al. Chem Sci. 2018 Sep 5;9(44):8352-8362. doi: 10.1039/c8sc01284a. eCollection 2018 Nov 28. Chem Sci. 2018. PMID: 30542582 Free PMC article. - Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel.
Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH, Laganowsky A. Liu Y, et al. Nat Commun. 2019 Mar 22;10(1):1352. doi: 10.1038/s41467-019-09333-4. Nat Commun. 2019. PMID: 30902995 Free PMC article. - Ionic and signaling mechanisms involved in neurotensin-mediated excitation of central amygdala neurons.
Lei S, Hu B. Lei S, et al. Neuropharmacology. 2021 Sep 15;196:108714. doi: 10.1016/j.neuropharm.2021.108714. Epub 2021 Jul 14. Neuropharmacology. 2021. PMID: 34271017 Free PMC article. - The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2.
Deng W, Mahajan R, Baumgarten CM, Logothetis DE. Deng W, et al. Pflugers Arch. 2016 May;468(5):817-24. doi: 10.1007/s00424-016-1794-9. Epub 2016 Feb 2. Pflugers Arch. 2016. PMID: 26837888 Free PMC article.