Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys - PubMed (original) (raw)
Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys
B Lavoie et al. Neuroreport. 1991 Oct.
Abstract
In cynomolgus monkeys, midbrain neurons immunoreactive (IR) for the calcium-binding protein calbindin D-28k (CaBP) occur principally in the dorsal tier of substantia nigra pars compacta (SNc) and in the ventral tegmental area (VTA), and most of these neurons co-express tyrosine hydroxylase (TH). In monkeys rendered parkinsonian (PD) after MPTP injections, CaBP-IR neurons are much less severely affected than TH-IR neurons in SNc and in VTA, and most spared neurons in SNc/VTA display both CaBP and TH immunoreactivity. These results reveal that, in contrast to the situation in other neurodegenerative diseases, CaBP may be used as a marker for a specific neuronal population that is less prone to degeneration in Parkinson's disease.
Similar articles
- Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells.
German DC, Manaye KF, Sonsalla PK, Brooks BA. German DC, et al. Ann N Y Acad Sci. 1992 May 11;648:42-62. doi: 10.1111/j.1749-6632.1992.tb24523.x. Ann N Y Acad Sci. 1992. PMID: 1353337 - Effects of dopamine denervation on striatal peptide expression in parkinsonian monkeys.
Lavoie B, Parent A, Bédard PJ. Lavoie B, et al. Can J Neurol Sci. 1991 Aug;18(3 Suppl):373-5. doi: 10.1017/s0317167100032467. Can J Neurol Sci. 1991. PMID: 1933683 - Midbrain dopaminergic neurons in the mouse: co-localization with Calbindin-D28K and calretinin.
Liang CL, Sinton CM, German DC. Liang CL, et al. Neuroscience. 1996 Nov;75(2):523-33. doi: 10.1016/0306-4522(96)00228-x. Neuroscience. 1996. PMID: 8931015 - The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons.
Simeone A, Di Salvio M, Di Giovannantonio LG, Acampora D, Omodei D, Tomasetti C. Simeone A, et al. Mol Neurobiol. 2011 Apr;43(2):107-13. doi: 10.1007/s12035-010-8148-y. Epub 2010 Nov 18. Mol Neurobiol. 2011. PMID: 21086067 Review. - Are you or aren't you? Challenges associated with physiologically identifying dopamine neurons.
Ungless MA, Grace AA. Ungless MA, et al. Trends Neurosci. 2012 Jul;35(7):422-30. doi: 10.1016/j.tins.2012.02.003. Epub 2012 Mar 28. Trends Neurosci. 2012. PMID: 22459161 Free PMC article. Review.
Cited by
- Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model.
Del Rey NL, Hernández-Pinedo N, Carrillo M, Del Cerro M, Esteban-García N, Trigo-Damas I, Monje MHG, Lanciego JL, Cavada C, Obeso JA, Blesa J. Del Rey NL, et al. NPJ Parkinsons Dis. 2024 Sep 2;10(1):165. doi: 10.1038/s41531-024-00777-0. NPJ Parkinsons Dis. 2024. PMID: 39223183 Free PMC article. - Unbiased Stereological Estimates of Dopaminergic and GABAergic Neurons in the A10, A9, and A8 Subregions in the Young Male Macaque.
Kelly EA, Contreras J, Duan A, Vassell R, Fudge JL. Kelly EA, et al. Neuroscience. 2022 Aug 1;496:152-164. doi: 10.1016/j.neuroscience.2022.06.018. Epub 2022 Jun 20. Neuroscience. 2022. PMID: 35738547 Free PMC article. - Mapping of the colocalization of calretinin and tyrosine hydroxylase in the rat substantia nigra and ventral tegmental area.
Isaacs KR, Jacobowitz DM. Isaacs KR, et al. Exp Brain Res. 1994;99(1):34-42. doi: 10.1007/BF00241410. Exp Brain Res. 1994. PMID: 7925794 - Inhibition of West Nile virus by calbindin-D28k.
Siddharthan V, Wang H, Davies CJ, Hall JO, Morrey JD. Siddharthan V, et al. PLoS One. 2014 Sep 2;9(9):e106535. doi: 10.1371/journal.pone.0106535. eCollection 2014. PLoS One. 2014. PMID: 25180779 Free PMC article. - The role of Ca2+ signaling in Parkinson's disease.
Zaichick SV, McGrath KM, Caraveo G. Zaichick SV, et al. Dis Model Mech. 2017 May 1;10(5):519-535. doi: 10.1242/dmm.028738. Dis Model Mech. 2017. PMID: 28468938 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous