Human and mouse hemoglobin association with the transgenic mouse erythrocyte membrane - PubMed (original) (raw)

Comparative Study

. 2006 Aug 7;580(18):4485-90.

doi: 10.1016/j.febslet.2006.07.021. Epub 2006 Jul 17.

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• PMID: 16860794
• DOI: 10.1016/j.febslet.2006.07.021

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Comparative Study

Human and mouse hemoglobin association with the transgenic mouse erythrocyte membrane

Qiuying Chen et al. FEBS Lett. 2006.

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Abstract

Transgenic mouse models of hemoglobinopathies unravel pathophysiological mechanisms; yet the validity of the red blood cell (RBC) model of human hemoglobin (hHb) enveloped by a mouse (m) membrane has been questioned. Isoelectric focusing of hHb and mHb from transgenic mRBC shows a greater association of mHb to the mouse membrane compared to normal hHbA, supporting a species-specific Hb-mRBC membrane interaction. Enhanced hmutant Hb (HbE, HbS and HbC)-mRBC membrane affinities correlates with enhanced membrane lipid peroxidation and parallel those reported in hRBC, lending support to transgenic mRBC as models of hemoglobinopathies. Species-specific Hb-membrane interaction may be overridden by Hb charge and conformational alterations.

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