Targeting XBP-1 as a novel anti-cancer strategy - PubMed (original) (raw)
Review
doi: 10.4161/cbt.5.7.2973. Epub 2006 Jul 1.
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- PMID: 16861911
- DOI: 10.4161/cbt.5.7.2973
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Review
Targeting XBP-1 as a novel anti-cancer strategy
Albert C Koong et al. Cancer Biol Ther. 2006 Jul.
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Abstract
The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.
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