Activated signal transduction kinases frequently occupy target genes - PubMed (original) (raw)
. 2006 Jul 28;313(5786):533-6.
doi: 10.1126/science.1127677.
Affiliations
- PMID: 16873666
- DOI: 10.1126/science.1127677
Activated signal transduction kinases frequently occupy target genes
Dmitry K Pokholok et al. Science. 2006.
Abstract
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in the yeast (Saccharomyces cerevisiae) genome. The ability to detect this interaction of signaling kinases with target genes can be used to more precisely and comprehensively map the regulatory circuitry that eukaryotic cells use to respond to their environment.
Comment in
- Cell signaling. Protein kinases seek close encounters with active genes.
Edmunds JW, Mahadevan LC. Edmunds JW, et al. Science. 2006 Jul 28;313(5786):449-51. doi: 10.1126/science.1131158. Science. 2006. PMID: 16873633 No abstract available.
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