Functional role of spliced cytoplasmic tails in P2X2-receptor-mediated cellular signaling - PubMed (original) (raw)
Review
doi: 10.1254/jphs.cpj06012x. Epub 2006 Aug 5.
Affiliations
- PMID: 16891773
- DOI: 10.1254/jphs.cpj06012x
Free article
Review
Functional role of spliced cytoplasmic tails in P2X2-receptor-mediated cellular signaling
Taka-aki Koshimizu et al. J Pharmacol Sci. 2006 Aug.
Free article
Abstract
P2X receptors belong to a unique family of ligand-gated channels in terms of their molecular architecture, in which the channel subunit has two transmembrane alpha-helixes with a large extracellular loop keeping amino- and carboxy-termini in the cytoplasm. Post-transcriptional modifications of P2X receptors could diversify cellular responsiveness induced by extracellular ATP in anterior pituitary cells and other cell types. Recently, we found a spliced variant P2X2 transcript, termed P2X2e, in mouse pituitary. The P2X2e has a shorter cytoplasmic carboxy-terminal tail than those of full-length P2X2a or splice variant P2X2b subunits. Although ATP induced rapid responses in all homomeric P2X2 channels, the current induced by P2X2e declined significantly faster than those by P2X2a or P2X2b. In this article, we summarize functional alterations of P2X2 receptors after splicing reactions. Combinations of different P2X2 subunit carboxy-termini to form homomeric and heteromeric channels could be a molecular mechanism for promoting functional diversities of ATP-induced cellular signals.
Similar articles
- Carboxyl-terminal splicing enhances physical interactions between the cytoplasmic tails of purinergic P2X receptors.
Koshimizu TA, Kretschmannova K, He ML, Ueno S, Tanoue A, Yanagihara N, Stojilkovic SS, Tsujimoto G. Koshimizu TA, et al. Mol Pharmacol. 2006 May;69(5):1588-98. doi: 10.1124/mol.105.019802. Epub 2006 Feb 8. Mol Pharmacol. 2006. PMID: 16467187 - Functional role of alternative splicing in pituitary P2X2 receptor-channel activation and desensitization.
Koshimizu T, Tomić M, Van Goor F, Stojilkovic SS. Koshimizu T, et al. Mol Endocrinol. 1998 Jul;12(7):901-13. doi: 10.1210/mend.12.7.0129. Mol Endocrinol. 1998. PMID: 9658396 - Localization and functional expression of splice variants of the P2X2 receptor.
Simon J, Kidd EJ, Smith FM, Chessell IP, Murrell-Lagnado R, Humphrey PP, Barnard EA. Simon J, et al. Mol Pharmacol. 1997 Aug;52(2):237-48. doi: 10.1124/mol.52.2.237. Mol Pharmacol. 1997. PMID: 9271346 - Molecular physiology of P2X receptors.
North RA. North RA. Physiol Rev. 2002 Oct;82(4):1013-67. doi: 10.1152/physrev.00015.2002. Physiol Rev. 2002. PMID: 12270951 Review. - [ATP receptors in pain].
Tsuda M, Koizumi S, Inoue K. Tsuda M, et al. Nihon Yakurigaku Zasshi. 2000 Dec;116(6):343-50. doi: 10.1254/fpj.116.343. Nihon Yakurigaku Zasshi. 2000. PMID: 11188502 Review. Japanese.
Cited by
- The penultimate arginine of the carboxyl terminus determines slow desensitization in a P2X receptor from the cattle tick Boophilus microplus.
Bavan S, Farmer L, Singh SK, Straub VA, Guerrero FD, Ennion SJ. Bavan S, et al. Mol Pharmacol. 2011 Apr;79(4):776-85. doi: 10.1124/mol.110.070037. Epub 2011 Jan 6. Mol Pharmacol. 2011. PMID: 21212138 Free PMC article. - Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells.
Morton-Jones RT, Vlajkovic SM, Thorne PR, Cockayne DA, Ryan AF, Housley GD. Morton-Jones RT, et al. Purinergic Signal. 2015 Dec;11(4):551-60. doi: 10.1007/s11302-015-9473-4. Epub 2015 Oct 1. Purinergic Signal. 2015. PMID: 26424615 Free PMC article. - Molecular and functional properties of P2X receptors--recent progress and persisting challenges.
Kaczmarek-Hájek K, Lörinczi E, Hausmann R, Nicke A. Kaczmarek-Hájek K, et al. Purinergic Signal. 2012 Sep;8(3):375-417. doi: 10.1007/s11302-012-9314-7. Epub 2012 May 1. Purinergic Signal. 2012. PMID: 22547202 Free PMC article. Review. - Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells.
Delic J, Zimmermann H. Delic J, et al. Purinergic Signal. 2010 Dec;6(4):417-28. doi: 10.1007/s11302-010-9206-7. Epub 2011 Jan 6. Purinergic Signal. 2010. PMID: 21437012 Free PMC article. - Neurotransmitter receptors as signaling platforms in anterior pituitary cells.
Zemková H, Stojilkovic SS. Zemková H, et al. Mol Cell Endocrinol. 2018 Mar 5;463:49-64. doi: 10.1016/j.mce.2017.07.003. Epub 2017 Jul 3. Mol Cell Endocrinol. 2018. PMID: 28684290 Free PMC article. Review.