Advanced glycation end products: sparking the development of diabetic vascular injury - PubMed (original) (raw)
Review
Advanced glycation end products: sparking the development of diabetic vascular injury
Alison Goldin et al. Circulation. 2006.
Abstract
Advanced glycation end products (AGEs) are proteins or lipids that become glycated after exposure to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the development of atherosclerosis. The presence and accumulation of AGEs in many different cell types affect extracellular and intracellular structure and function. AGEs contribute to a variety of microvascular and macrovascular complications through the formation of cross-links between molecules in the basement membrane of the extracellular matrix and by engaging the receptor for advanced glycation end products (RAGE). Activation of RAGE by AGEs causes upregulation of the transcription factor nuclear factor-kappaB and its target genes. Soluble AGEs activate monocytes, and AGEs in the basement membrane inhibit monocyte migration. AGE-bound RAGE increases endothelial permeability to macromolecules. AGEs block nitric oxide activity in the endothelium and cause the production of reactive oxygen species. Because of the emerging evidence about the adverse effects of AGEs on the vasculature of patients with diabetes, a number of different therapies to inhibit AGEs are under investigation.
Similar articles
- Advanced glycation end products and diabetic foot disease.
Huijberts MS, Schaper NC, Schalkwijk CG. Huijberts MS, et al. Diabetes Metab Res Rev. 2008 May-Jun;24 Suppl 1:S19-24. doi: 10.1002/dmrr.861. Diabetes Metab Res Rev. 2008. PMID: 18442180 Review. - Advanced glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells.
Takahashi HK, Mori S, Wake H, Liu K, Yoshino T, Ohashi K, Tanaka N, Shikata K, Makino H, Nishibori M. Takahashi HK, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):89-98. doi: 10.1124/jpet.109.150581. Epub 2009 Apr 20. J Pharmacol Exp Ther. 2009. PMID: 19380603 - Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury.
Soulis T, Thallas V, Youssef S, Gilbert RE, McWilliam BG, Murray-McIntosh RP, Cooper ME. Soulis T, et al. Diabetologia. 1997 Jun;40(6):619-28. doi: 10.1007/s001250050725. Diabetologia. 1997. PMID: 9222639 - RAGE biology, atherosclerosis and diabetes.
Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA. Barlovic DP, et al. Clin Sci (Lond). 2011 Jul;121(2):43-55. doi: 10.1042/CS20100501. Clin Sci (Lond). 2011. PMID: 21457145 Review. - Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes.
Gu L, Hagiwara S, Fan Q, Tanimoto M, Kobata M, Yamashita M, Nishitani T, Gohda T, Ni Z, Qian J, Horikoshi S, Tomino Y. Gu L, et al. Nephrol Dial Transplant. 2006 Feb;21(2):299-313. doi: 10.1093/ndt/gfi210. Epub 2005 Nov 1. Nephrol Dial Transplant. 2006. PMID: 16263740
Cited by
- Understanding Diabetic Neuropathy: Focus on Oxidative Stress.
Pang L, Lian X, Liu H, Zhang Y, Li Q, Cai Y, Ma H, Yu X. Pang L, et al. Oxid Med Cell Longev. 2020 Jul 31;2020:9524635. doi: 10.1155/2020/9524635. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32832011 Free PMC article. Review. - Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells.
Zhang X, Rodriguez-Niño A, Pastene DO, Pallavi P, van den Born J, Bakker SJL, Krämer BK, Yard BA. Zhang X, et al. Sci Rep. 2021 Apr 13;11(1):8004. doi: 10.1038/s41598-021-87561-9. Sci Rep. 2021. PMID: 33850227 Free PMC article. - Achilles' Heel-The Significance of Maintaining Microenvironmental Homeostasis in the Nucleus Pulposus for Intervertebral Discs.
Luo Z, Wei Z, Zhang G, Chen H, Li L, Kang X. Luo Z, et al. Int J Mol Sci. 2023 Nov 22;24(23):16592. doi: 10.3390/ijms242316592. Int J Mol Sci. 2023. PMID: 38068915 Free PMC article. Review. - Arterial stiffness is associated with diabetic retinopathy in Korean type 2 diabetic patients.
Yun YW, Shin MH, Lee YH, Rhee JA, Choi JS. Yun YW, et al. J Prev Med Public Health. 2011 Nov;44(6):260-6. doi: 10.3961/jpmph.2011.44.6.260. J Prev Med Public Health. 2011. PMID: 22143176 Free PMC article. - Advanced glycation end products impair K(Ca)3.1- and K(Ca)2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries.
Zhao LM, Wang Y, Ma XZ, Wang NP, Deng XL. Zhao LM, et al. Pflugers Arch. 2014 Feb;466(2):307-17. doi: 10.1007/s00424-013-1324-y. Epub 2013 Jul 20. Pflugers Arch. 2014. PMID: 23873353
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources