The anaphase promoting complex/cyclosome: a machine designed to destroy - PubMed (original) (raw)

Review

doi: 10.1038/nrm1988. Epub 2006 Aug 9.

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• PMID: 16896351
• DOI: 10.1038/nrm1988

Review

The anaphase promoting complex/cyclosome: a machine designed to destroy

Jan-Michael Peters. Nat Rev Mol Cell Biol. 2006 Sep.

Abstract

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

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