In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs - PubMed (original) (raw)

. 1990 Mar 8;344(6262):126-32.

doi: 10.1038/344126a0.

Affiliations

• PMID: 1689810
• DOI: 10.1038/344126a0

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

G L Yu et al. Nature. 1990.

Abstract

Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for telomerase in vivo.

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Comment in

• Telomerase RNA: tying up the loose ends.
  Gall JG. Gall JG. Nature. 1990 Mar 8;344(6262):108-9. doi: 10.1038/344108a0. Nature. 1990. PMID: 1689808 No abstract available.

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