What is the hair cell transduction channel? - PubMed (original) (raw)

Review

What is the hair cell transduction channel?

David P Corey. J Physiol. 2006.

Abstract

In contrast to nearly all other sensory systems, the mechanically sensitive ion channel carrying the receptor current into hair cells of the inner ear has not been identified in molecular terms. A number of candidates from at least two different ion channel families have been considered: these include the epithelial sodium channel (ENaC) and acid-sensing ion channel (ASIC) members of the DEG/ENaC superfamily of amiloride-sensitive sodium channels, as well as the TRP channels TRPN1, TRPV4, TRPML3 and TRPA1. For each, initial supportive results were followed by further studies that cast doubts on their involvement. No promising candidates have recently emerged, but the TRP family continues to be attractive in general.

PubMed Disclaimer

Similar articles

• TRP channels as candidates for hearing and balance abnormalities in vertebrates.
  Cuajungco MP, Grimm C, Heller S. Cuajungco MP, et al. Biochim Biophys Acta. 2007 Aug;1772(8):1022-7. doi: 10.1016/j.bbadis.2007.01.002. Epub 2007 Jan 17. Biochim Biophys Acta. 2007. PMID: 17300924 Free PMC article. Review.
• DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature.
  Askwith CC, Benson CJ, Welsh MJ, Snyder PM. Askwith CC, et al. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6459-63. doi: 10.1073/pnas.111155398. Epub 2001 May 15. Proc Natl Acad Sci U S A. 2001. PMID: 11353858 Free PMC article.
• DEG/ENaC channels: a touchy superfamily that watches its salt.
  Mano I, Driscoll M. Mano I, et al. Bioessays. 1999 Jul;21(7):568-78. doi: 10.1002/(SICI)1521-1878(199907)21:7<568::AID-BIES5>3.0.CO;2-L. Bioessays. 1999. PMID: 10472184 Review.
• Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells.
  Shin JB, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gründer S. Shin JB, et al. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12572-7. doi: 10.1073/pnas.0502403102. Epub 2005 Aug 22. Proc Natl Acad Sci U S A. 2005. PMID: 16116094 Free PMC article.
• Vertebrate and invertebrate TRPV-like mechanoreceptors.
  Mutai H, Heller S. Mutai H, et al. Cell Calcium. 2003 May-Jun;33(5-6):471-8. doi: 10.1016/s0143-4160(03)00062-9. Cell Calcium. 2003. PMID: 12765692 Review.

Cited by

• Evidence for involvement of TRPA1 in the detection of vibrations by hair bundle mechanoreceptors in sea anemones.
  Mahoney JL, Graugnard EM, Mire P, Watson GM. Mahoney JL, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Jul;197(7):729-42. doi: 10.1007/s00359-011-0636-7. Epub 2011 Mar 11. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011. PMID: 21394510
• Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.
  Pan B, Waguespack J, Schnee ME, LeBlanc C, Ricci AJ. Pan B, et al. J Neurophysiol. 2012 May;107(9):2408-20. doi: 10.1152/jn.01178.2011. Epub 2012 Feb 8. J Neurophysiol. 2012. PMID: 22323630 Free PMC article.
• Primary processes in sensory cells: current advances.
  Frings S. Frings S. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jan;195(1):1-19. doi: 10.1007/s00359-008-0389-0. Epub 2008 Nov 15. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009. PMID: 19011871 Review.
• Potassium ion movement in the inner ear: insights from genetic disease and mouse models.
  Zdebik AA, Wangemann P, Jentsch TJ. Zdebik AA, et al. Physiology (Bethesda). 2009 Oct;24:307-16. doi: 10.1152/physiol.00018.2009. Physiology (Bethesda). 2009. PMID: 19815857 Free PMC article. Review.
• Otoacoustic emissions from insect ears: evidence of active hearing?
  Kössl M, Möckel D, Weber M, Seyfarth EA. Kössl M, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008 Jul;194(7):597-609. doi: 10.1007/s00359-008-0344-0. Epub 2008 May 31. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008. PMID: 18516607 Review.

References

1. 1. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269–1282. - PubMed
2. 1. Cable J, Steel KP. Combined cochleo-saccular and neuroepithelial abnormalities in the varitint-waddler-j (vaj) mouse. Hear Res. 1998;123:125–136. - PubMed
3. 1. Canessa CM, Horisberger JD, Rossier BC. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 1993;361:467–470. - PubMed
4. 1. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367:463–467. - PubMed
5. 1. Chalfie M, Au M. Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science. 1989;243:1027–1033. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • PubMed Central
  • Wiley

• Miscellaneous

  • NCI CPTAC Assay Portal