Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity - PubMed (original) (raw)
Review
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity
Sayuri Yamazaki et al. Immunol Rev. 2006 Aug.
Abstract
Thymic derived naturally occurring CD25+ CD4+ T regulatory cells (Tregs) suppress immune responses, including transplantation. Here we discuss the capacity of dendritic cells (DCs) to expand antigen-specific Tregs, particularly polyclonal Tregs directed to alloantigens. Initial studies have shown that mature DCs are specialized antigen-presenting cells (APCs) for expanding antigen-specific CD25+ CD4+ Tregs from TCR transgenic mice. When triggered by specific antigen, these Tregs act back on immature DCs to block the upregulation of CD80 and CD86 costimulatory molecules. More recently, DCs have been used to expand alloantigen-specific CD25+ CD4+ Tregs from the polyclonal repertoire in the presence of interleukin-2 (IL-2). Allogeneic DCs are much more effective than allogeneic spleen cells for expanding CD25+ CD4+ Tregs. The DC-expanded Tregs continue to express high levels of Foxp3, even without supplemental IL-2, whereas spleen cells poorly sustain Foxp3 expression. When suppressive activity is tested, relatively small numbers of DC-expanded CD25+ CD4+ Tregs exert antigen-specific suppression in the mixed leukocyte reaction (MLR), blocking immune responses to the original stimulating strain 10 times more effectively than to third party stimulating cells. DC-expanded Tregs also retard graft versus host disease (GVHD) across full major histocompatibility complex (MHC) barriers. In vitro and in vivo, the alloantigen-specific CD25+ CD4+ Tregs are much more effective suppressors of transplantation reactions than polyclonal populations. We suggest that the expansion of Tregs from a polyclonal repertoire via antigen-presenting DCs will provide a means for antigen-specific control of unwanted immune reactions.
Similar articles
- Comparative analysis of dendritic cells and anti-CD3/CD28 expanded regulatory T cells for application in transplantation.
Zeng M, Guinet E, Nouri-Shirazi M. Zeng M, et al. Transpl Immunol. 2009 Dec;22(1-2):82-92. doi: 10.1016/j.trim.2009.07.004. Epub 2009 Jul 25. Transpl Immunol. 2009. PMID: 19635560 - Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts.
Giorgini A, Noble A. Giorgini A, et al. J Leukoc Biol. 2007 Nov;82(5):1053-61. doi: 10.1189/jlb.0407227. Epub 2007 Aug 7. J Leukoc Biol. 2007. PMID: 17684039 - Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
Yamazaki S, Patel M, Harper A, Bonito A, Fukuyama H, Pack M, Tarbell KV, Talmor M, Ravetch JV, Inaba K, Steinman RM. Yamazaki S, et al. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2758-63. doi: 10.1073/pnas.0510606103. Epub 2006 Feb 10. Proc Natl Acad Sci U S A. 2006. PMID: 16473944 Free PMC article. - Alloantigen specific T regulatory cells in transplant tolerance.
Hall BM, Tran G, Hodgkinson SJ. Hall BM, et al. Int Immunopharmacol. 2009 May;9(5):570-4. doi: 10.1016/j.intimp.2009.01.016. Epub 2009 Jan 29. Int Immunopharmacol. 2009. PMID: 19539571 Review. - The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity.
Tarbell KV, Yamazaki S, Steinman RM. Tarbell KV, et al. Semin Immunol. 2006 Apr;18(2):93-102. doi: 10.1016/j.smim.2006.01.009. Epub 2006 Feb 15. Semin Immunol. 2006. PMID: 16469503 Review.
Cited by
- Immune Escape Strategies in Head and Neck Cancer: Evade, Resist, Inhibit, Recruit.
Kostecki KL, Iida M, Crossman BE, Salgia R, Harari PM, Bruce JY, Wheeler DL. Kostecki KL, et al. Cancers (Basel). 2024 Jan 11;16(2):312. doi: 10.3390/cancers16020312. Cancers (Basel). 2024. PMID: 38254801 Free PMC article. Review. - Cell-based therapies for the treatment of rheumatoid arthritis.
Moghaddam MZ, Mousavi MJ, Ghotloo S. Moghaddam MZ, et al. Immun Inflamm Dis. 2023 Nov;11(11):e1091. doi: 10.1002/iid3.1091. Immun Inflamm Dis. 2023. PMID: 38018576 Free PMC article. Review. - Role of Regulatory T Cells and Their Potential Therapeutic Applications in Celiac Disease.
Camarca A, Rotondi Aufiero V, Mazzarella G. Camarca A, et al. Int J Mol Sci. 2023 Sep 22;24(19):14434. doi: 10.3390/ijms241914434. Int J Mol Sci. 2023. PMID: 37833882 Free PMC article. Review. - The immunoregulatory effect of the TREM2-agonist Sulfavant A in human allogeneic mixed lymphocyte reaction.
Barra G, Gallo C, Carbone D, Ziaco M, Dell'Isola M, Affuso M, Manzo E, Nuzzo G, Fioretto L, D'Ippolito G, De Palma R, Fontana A. Barra G, et al. Front Immunol. 2023 Feb 14;14:1050113. doi: 10.3389/fimmu.2023.1050113. eCollection 2023. Front Immunol. 2023. PMID: 36865548 Free PMC article. - Toward Establishing an Ideal Adjuvant for Non-Inflammatory Immune Enhancement.
Seya T, Tatematsu M, Matsumoto M. Seya T, et al. Cells. 2022 Dec 11;11(24):4006. doi: 10.3390/cells11244006. Cells. 2022. PMID: 36552770 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous